ArticleJournal of patient experience2026
Participant Experience, Acceptability and Feasibility of Virtual and Digitally Supported Visits in a Phase IIa COPD Trial.
Article in Journal of patient experience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05492877 (A Phase IIa Randomised, Double Blind, Placebo Controlled, Parallel Arm, Multi-Centre Study to Evaluate the Efficacy and Safety of Mitiperstat), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase IIa Randomised, Double Blind, Placebo Controlled, Parallel Arm, Multi-Centre Study to Evaluate the Efficacy and Safety of Mitiperstat (AZD4831), for 12-24 Weeks, in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
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Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding participant experience is crucial for improving participant satisfaction, retention, data quality, and clinical trial efficiency; particularly when incorporating digital patient solutions and virtual elements. CRESCENDO, an international phase-II chronic obstructive pulmonary disease (COPD) trial, incorporated daily at-home digital measurements, remote coached spirometry, and a virtual visit to evaluate feasibility and participant acceptance. This study explored participant experience in CRESCENDO through semi-structured interviews (n=21) and a Study Participant Feedback Questionnaire (SPFQ, n=81), conducted across Bulgaria, Canada, Poland, Spain, UK, and USA. Interview data were analysed thematically. Participants were generally satisfied and found digital and virtual elements user-friendly, although technical issues caused frustration. When functioning properly, participants considered remote and in-person spirometry coaching comparable. Nonetheless, participants preferred in-person visits due to positive interactions with trial staff, which increased satisfaction and feeling of appreciation. High concordance between interview and SPFQ data supported the validity of qualitative interviews for assessing participant experience. The study highlights the potential of digital elements and offers practical recommendations, like providing options for in-person and virtual visits, to enhance satisfaction and engagement. This qualitative sub-study was conducted within the CRESCENDO trial (https://clinicaltrials.gov reference: NCT05492877).
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