ArticleFrontiers in neurology2026
Low hemoglobin-albumin-lymphocyte-platelet score as a risk marker for stroke-associated pneumonia in acute ischemic stroke: a retrospective cohort study.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Stroke-associated pneumonia (SAP) is a common and serious complication of acute ischemic stroke (AIS). The hemoglobin, albumin, lymphocyte, and platelet (HALP) score reflects nutritional, inflammatory, and immune status, but its association with SAP remains unclear. Methods: We retrospectively analyzed 1,766 consecutive AIS patients admitted between January 2019 and December 2023. HALP was calculated from blood tests obtained within 48 h of admission. Multivariable logistic regression, receiver operating characteristic analysis, subgroup analysis, generalized additive modeling, and two-piecewise logistic regression were used to evaluate the association between HALP and SAP and to explore threshold effects. Results: SAP occurred in 376 patients (21.3%). HALP was significantly lower in patients with SAP than in those without SAP [35.08 (18.59-51.86) vs. 44.55 (31.29-63.25), Conclusion: Low HALP score was independently and non-linearly associated with SAP in AIS, with an exploratory threshold near 27.7 that may help inform future risk-stratification research.
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