ArticleActa medica Philippina2026
Usage of Multiplex Polymerase Chain Reaction (PCR) Panels at a Single Tertiary Hospital in Manila: Most Common Pathogens Detected and Implications on Antimicrobial Therapy.
Article in Acta medica Philippina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Objectives: Multiplex Polymerase Chain Reaction (PCR) is an emerging diagnostic tool used to rapidly detect infectious disease pathogens, aiding decision-making in antimicrobial therapy. This study aims to describe the usage of multiplex PCR (BioFire Methods: Panel results were retrieved with assistance from the laboratory staff through the hospital information systems (HIS), and patient demographics and antimicrobial therapy from the HIS. Descriptive analysis was done. Results: Among adult patients subjected to Multiplex PCR panels in Asian Hospital and Medical Center in the period specified above, the most requested was the Respiratory panel, followed by the Pneumonia panel, GI panel, and ME panel. Pneumonia panel has the highest positivity rate at 61%, followed by the GI panel at 42.1%, the ME panel at 40%, and the respiratory panel at 18.3%. The majority of the respiratory panel pathogens were community-acquired, with SARS-CoV-2, Influenza A, and Rhinovirus/Enterovirus as the most commonly detected pathogens. Pneumonia panel pathogens were mostly hospital-acquired, with Conclusion: This study determined the most common pathogens detected in Multiplex PCR panels in Asian Hospital and Medical Center as above. Awareness of the etiologic agents for all 4 panels appeared useful in the decision-making on antimicrobial therapy. In the respiratory panel, the majority resulted in starting new anti-microbials (32.4%), followed by continuing anti-microbials (23.1%). In the pneumonia panel, it seemed like the majority had already started the appropriate empiric therapy since most continued with the present antibiotics (51.7%), followed by starting (22.8%) and shifting (18.3%) antimicrobials. In the GI panel, most also continued with the current antibiotics (29.5%), closely followed by starting (17.6%), remaining without anti-microbials (17.6%), and shifting antimicrobials (11.8%). It is in the ME panel that most started with new anti-microbials (44.5%) and stopped (33.3%) specific anti-microbials. The study underscores the value of multiplex PCR in enhancing diagnostic accuracy and guiding anti-microbial decision-making.
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