Evidence map›Paper›PMID 42661891›Full record

ArticleFrontiers in immunology2026

Single-cell and spatial landscape reveals impaired tertiary lymphoid structure maturation in

Nenglin Zhang, Qiuyu Jiang, Qian Ma, Haisheng Huang, Lijie Ma, Shuping Zhou

Abstract read
PubMed Full text at PMC Publisher
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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nenglin Zhang *Department of Gastroenterology, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, China.
Qiuyu Jiang *Department of Gastroenterology and Hepatology, Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China.
Qian Ma *Department of Gastroenterology, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, China.
Haisheng HuangDepartment of Dermatology, The Children's Hospital of Fudan University, Shanghai, China.
Lijie MaDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Shuping ZhouDepartment of Gastroenterology, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tertiary lymphoid structures (TLSs) are key immune niches involved in antitumor immunity. However, their functional impact depends on spatial localization, maturation status, and cellular composition within the tumor immune microenvironment (TIME). Despite the recognized role of Methods: We integrated public single-cell RNA sequencing (scRNA-seq; HRA000704, GSE150290, and GSE249874; n=36), spatial transcriptomics (ST; GSE251950; n=9), and multiplex immunofluorescence (mIF) staining (n=90) to comprehensively profile TLSs across Results: Conclusions: Our study identifies an

Indexed as

Helicobacter InfectionsHelicobacter pyloriStomach NeoplasmsTertiary Lymphoid StructuresHumansSingle-Cell AnalysisSpatial TranscriptomicsTumor Microenvironmentgastric cancerHelicobacter pyloriHSP70immunotherapytertiary lymphoid structure

Identifiers

PMID42661891
PMCPMC13518559

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.