Evidence map›Paper›PMID 42661868›Full record

ArticleiMeta2026

The role of human microbiota in breast cancer pathogenesis and treatment.

Jie Qiu, Xiaojia Wang, Man Li, Jing Guo, Shipeng Ning, Yi-Zhou Gao, Xinyi Zhang, Xuli Meng, Yiding Chen, Yunxiang Zhou

Abstract read
In one paragraph

Article in iMeta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie QiuDepartment of Breast and Thyroid Surgery Shaoxing People's Hospital Shaoxing Zhejiang China.
Xiaojia WangDepartment of Breast Medical Oncology Zhejiang Cancer Hospital Hangzhou Zhejiang China.
Man LiDepartment of Breast Oncology The Second Hospital of Dalian Medical University Dalian Liaoning China.
Jing GuoDepartment of Microbiology and Immunology Stanford University School of Medicine Stanford California USA.
Shipeng NingDepartment of Breast Surgery The Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi China.
Yi-Zhou GaoDepartment of Environmental Hygiene, School of Public Health Harbin Medical University Harbin Heilongjiang China.
Xinyi ZhangDivision of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), Partner Site Essen A Partnership Between German Cancer Research Center (DKFZ) and University Hospital Essen Essen Nordrhein-Westfalen Germany.
Xuli MengCancer Center, Department of Breast Surgery Zhejiang Provincial People's Hospital Hangzhou Zhejiang China.
Yiding ChenDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China.
Yunxiang ZhouDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China.ORCID https://orcid.org/0000-0003-1000-0330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human microbiota contributes to breast cancer pathogenesis and treatment response through interactions involving the oral, gut, and breast microbial niches. (Left) Multi-site dysbiosis is characterized by altered microbial composition and abundance across different anatomical sites. (Middle) Microbial components and metabolites influence tumor progression and the tumor microenvironment through mechanisms including immune, metabolic, and inflammatory regulation. (Right) The microbiota and their metabolites further affect therapeutic efficacy and toxicity in immunotherapy, chemotherapy, endocrine therapy, and human epidermal growth factor receptor 2 (HER2)-targeted therapy, highlighting the translational potential of microbiota-targeted strategies in breast cancer.

Identifiers

PMID42661868
PMCPMC13519087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.