ArticleJournal of the Endocrine Society2026
Adiposity, not chronological aging, is the dominant determinant of circulating testosterone in US adult men.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Adiposity, not chronological aging, is the dominant determinant of circulating testosterone in US adult men.Journal of the Endocrine Society · 2026Article
- Stress-associated testosterone suppression: central adaptation or hypogonadism?The Journal of clinical endocrinology and metabolism · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context: Age-related decline in serum testosterone is commonly cited as justification for testosterone replacement therapy, yet adiposity may represent a major modifiable determinant of circulating testosterone. Objective: To quantify the relative contributions of age, total adiposity, and visceral adiposity to circulating testosterone concentrations and prevalence of biochemical low testosterone in US adult men. Design: Cross-sectional nationally representative analysis. Setting: National Health and Nutrition Examination Survey (NHANES) 2011-2016. Participants: Men aged 20 to 59 years with valid serum testosterone measurements ( Main Outcome Measures: Total testosterone (ng/dL) and the prevalence of biochemical low testosterone (testosterone <300 ng/dL). Results: Age explained only 2.5% of the variation in circulating testosterone (pseudo- Conclusion: Measures of adiposity consistently demonstrated substantially stronger associations with circulating testosterone than chronological age alone. Waist circumference performed comparably to DXA-derived VAT, supporting its use as a clinically accessible marker of obesity-related testosterone suppression.
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Registered trials
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