Evidence map›Paper›PMID 42661804›Full record

ArticleFrontiers in neurology2026

The impact of stroke on intramuscular connective tissue in mice.

Xiaoxiao Zhao, Giulio Morri, Matteo D'Urso, Caterina Fede, Lucia Petrelli, Livia Vignozzi, Yunfeng Sun, Claudia Clair, Gabriele Deidda, Preeti Raghavan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoxiao ZhaoDepartment of Neurosciences, Institute of Human Anatomy, University of Padova, Padova, Italy.
Giulio MorriPadova Neuroscience Center (PNC), University of Padova, Padova, Italy.
Matteo D'UrsoPadova Neuroscience Center (PNC), University of Padova, Padova, Italy.
Caterina FedeDepartment of Neurosciences, Institute of Human Anatomy, University of Padova, Padova, Italy.
Lucia PetrelliDepartment of Neurosciences, Institute of Human Anatomy, University of Padova, Padova, Italy.
Livia VignozziNeuroscience Institute, National Research Council (CNR), Padova, Italy.
Yunfeng SunDepartment of Neurosciences, Institute of Human Anatomy, University of Padova, Padova, Italy.
Claudia ClairDepartment of Neurosciences, Institute of Human Anatomy, University of Padova, Padova, Italy.
Gabriele DeiddaPadova Neuroscience Center (PNC), University of Padova, Padova, Italy.
Preeti RaghavanDepartment of Physical Medicine and Rehabilitation, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Manuela AllegraPadova Neuroscience Center (PNC), University of Padova, Padova, Italy.
Carla SteccoDepartment of Neurosciences, Institute of Human Anatomy, University of Padova, Padova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies about post-stroke peripheral structural remodeling have been focused on muscle fiber alterations, while extracellular matrix (ECM) remodeling in musculoskeletal tissues remains unclear. This study examines changes in extracellular matrix (ECM), specifically hyaluronan (HA) and collagen, in forelimb muscles following distal middle cerebral artery occlusion (dMCAO) in mice. Methods: Twenty-two 8-week-old C57BL/6 mice (10 male, 12 female) were randomly assigned to the control group ( Results: HA concentrations were significantly elevated in both the left (stroke affected) forelimb muscles (63.74 ± 11.80 μg/g), and right (unaffected) forelimb muscles (64.16 ± 13.52 μg/g) of stroke mice compared to the controls (left: 50.07 ± 8.84 μg/g, Conclusion: The results revealed a systemic increase in HA concentration in the stroke group, while collagen levels remained unchanged. These findings provide biochemical evidence of early alterations in extracellular matrix composition after stroke.

Indexed as

CollagenConnective TissueHyaluronic AcidInfarction, Middle Cerebral ArteryMuscle, SkeletalStrokeAnimalsDisease Models, AnimalExtracellular MatrixFemaleForelimbMaleMiceMice, Inbred C57BLCollagenHyaluronic Acidcollagenextracellular matrixhyaluronanintramuscular connective tissuestroke

Identifiers

PMID42661804
PMCPMC13518577

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.