ArticleFrontiers in microbiology2026
Total flavonoids of Potentilla discolor alleviate type 2 diabetes by regulating gut microbiota and endogenous metabolites.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and aims: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with an high incidence rate worldwide. It has recently shown a trend toward affecting younger populations. Total flavonoids from Potentilla discolor Bunge (PB) are associated with antipyretic and antidiarrheal properties. Several studies have also reported that PB exhibits anti-T2DM effects. However, the interactions between PB, T2DM, and gut microbiota, and the underlying mechanisms responsible for PB-mediated regulation of gut microbiota, have not been fully elucidated. This study performed Methods: Ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS) was used to analyze the flavonoid components in PB. The db/db mice were used as the T2DM model to assess the therapeutic effects of PB. The relationships between PB, T2DM, and gut microbiota were analyzed by 16S rRNA sequencing technology, Results: In PB, we identified 41 compounds, including 8 flavonoids, 9 flavonols, and 2 dihydroflavonoids. PB effectively reduced the blood glucose and glycated hemoglobin (GHb) levels ( Conclusion: The present study demonstrates that PB contains several flavonoid components, which ameliorate glucose metabolism and alleviate organ injury in T2DM mice by restoring gut microbiota homeostasis. Furthermore, identification of 15 differential metabolites by fecal metabolomics provides important information for further in-depth mechanistic research.
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