ArticleFrontiers in surgery2026
Synchronous right colon adenocarcinoma and sigmoid endometriosis mimicking a second primary carcinoma: a case report.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Intestinal endometriosis is a benign gynecological condition that frequently involves the rectosigmoid colon. Its synchronous occurrence with colorectal cancer is exceptionally rare and diagnostically challenging, particularly when mimicking a second primary malignancy. We report a case of a 48-year-old woman presenting with altered bowel habits. Colonoscopy revealed synchronous lesions: an adenocarcinoma at the hepatic flexure and a suspicious mass in the sigmoid colon. Repeated biopsies of the sigmoid lesion were inconclusive, ranging from dysplasia to chronic inflammation, raising concern for a second primary tumor. The patient underwent right hemicolectomy with partial sigmoidectomy. Intraoperative frozen section unexpectedly identified endometriosis, subsequently confirmed by definitive pathology and immunohistochemistry. At 12-month follow-up, the patient remained well with no evidence of recurrence.
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