ArticleFrontiers in oncology2026
Efficacy and safety of immune checkpoint inhibitors combined with chemotherapy versus bevacizumab combined with chemotherapy in first-line treatment of driver gene-negative advanced non-squamous non-small cell lung cancer: a single-center retrospective study.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To compare the efficacy and safety of immune checkpoint inhibitors (ICIs) versus bevacizumab (both combined with chemotherapy) for first-line treatment of driver gene-negative advanced non-squamous non-small cell lung cancer (NSCLC). Methods: This single-center retrospective study enrolled 194 patients with driver gene-negative advanced non-squamous NSCLC treated at our hospital from May 1, 2019, to May 1, 2025: 79 received ICIs plus chemotherapy, and 115 received bevacizumab plus chemotherapy. Both groups received 4-6 cycles of combination therapy followed by maintenance therapy until disease progression or the end of the study. The primary endpoint was progression-free survival (PFS), and secondary endpoints included objective response rate (ORR), disease control rate (DCR), and adverse events (AEs). Results: Short-term efficacy: ORR was significantly higher in the ICIs plus chemotherapy group than in the bevacizumab plus chemotherapy group (41.77% vs 26.09%, Conclusions: For patients with driver gene-negative advanced non-squamous NSCLC, ICIs combined with chemotherapy are superior to bevacizumab combined with chemotherapy in terms of short-term efficacy and progression-free survival, with manageable but distinct adverse event profiles.
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