ReviewFrontiers in nutrition2026
Food-derived protein-based calcium chelates: digestive stability, intestinal transport, and bone-related functions.
Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional calcium supplements often show limited bioaccessibility and suboptimal gastrointestinal tolerance. Food-derived proteins, protein hydrolysates, and peptide-calcium chelates have been investigated as protein-based calcium chelates. This review organizes these systems along a structural continuum from proteins to hydrolysates and peptide-calcium chelates, in which enzymatic hydrolysis, fractionation, purification, and chelation reshape carrier composition, molecular weight distribution, and calcium coordination characteristics. Within this framework, this review examines the preparation strategies, molecular features, gastrointestinal stability, intestinal transport behavior, and bone-related functions of protein-based calcium chelates. Particular attention is given to the effects of chelate type, molecular weight distribution, peptide sequence, and coordination stability on calcium retention, solubility, and transport-related behavior during digestion, as well as their links with osteogenic responses, gut microbiota changes, and the gut-bone axis. Overall, this review provides a structured framework for evaluating food-derived protein-based calcium chelates and their potential application in food-based calcium delivery systems, while highlighting future needs in functional validation, product standardization, safety assessment, and clinically relevant evidence.
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Registered trials
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