Evidence map›Paper›PMID 42661649›Full record

ArticleFrontiers in microbiology2026

Correlation study of polysomnographic parameters, serological markers, and gut microbiota in patients with short-sleep insomnia: a real-world study.

Lu Liu, Hui-Jie Zhou, Hao-Chen Li, Ming-Zhen Li, Yun-Liang Sun, Ji-Wei Zhu, Jing-Lin Wu, Man-Lu Lu, Yan Yu, Fang Han and 1 more

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Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lu Liu *Department of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.
Hui-Jie Zhou *Department of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.
Hao-Chen Li *Department of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.
Ming-Zhen LiDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.
Yun-Liang SunDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.
Ji-Wei ZhuDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.
Jing-Lin WuDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.
Man-Lu LuDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.
Yan YuDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.
Fang HanDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.
Lei PanDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University, Hospital, Binzhou Medical University, Binzhou, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Emerging evidence suggests that the gut microbiota may play a role in sleep regulation via the microbiota-gut-brain axis; however, its relationship with objective sleep parameters and serological markers remains unclear. This study aimed to elucidate the relationship between polysomnographic, serological, and gut microbiota changes in patients with short sleep insomnia. Methods: Patients with short-sleep insomnia and controls underwent polysomnography. Serum and faecal samples were collected. Serum 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), melatonin (MT), and orexin A (OXA) were measured by ELISA. Gut microbiota composition was analysed using 16S rRNA sequencing. Spearman's partial correlation and redundancy analysis (RDA) were performed in the insomnia group with adjustment for relevant confounders. Results: Compared with controls, insomnia patients showed significantly reduced sleep efficiency (SE), total sleep time (TST), non-rapid eye movement (NREM) and REM sleep duration, and N2 and N3 sleep, accompanied by prolonged sleep latency (SL), REM latency, and wake after sleep onset (WASO) duration and its proportion, as well as increased spontaneous microarousals during total and NREM sleep, and the frequency of sleep stage transitions and awakenings, and the relative power of theta, alpha, and beta waves during NREM sleep and delta, theta, and alpha waves during REM sleep ( Conclusion: Short-sleep insomnia is associated with alterations in sleep parameters, serological indicators, and gut microbiota, suggesting that gut microbiota modulation may represent a potential therapeutic target.

Indexed as

electroencephalogramgut microbiotainsomnianeurotransmitterspolysomnography

Identifiers

PMID42661649
PMCPMC13518140

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.