ArticleFrontiers in immunology2026
ADHD-anchored partitioning of non-small cell lung cancer genetic covariance identifies
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Individuals with attention-deficit/hyperactivity disorder (ADHD) show an elevated incidence of non-small cell lung cancer (NSCLC), usually attributed to smoking. Innate immune activation and chronic inflammation are implicated in both, yet whether shared germline genetics include a component statistically independent of the measured current-smoking phenotype, and whether that liability has an innate immune dimension, remains unclear. Methods: We applied genomic structural equation modelling to GWAS summary statistics to partition genetic covariance into indirect and conditional direct components with respect to measured current smoking. Among twelve psychiatric and personality traits, only ADHD survived FDR and served as the primary exposure; neuroticism was retained as a secondary exploratory indicator. Component statistics underwent gene-level and tissue-enrichment analyses. We estimated ADHD and NSCLC genetic correlations with inflammatory biomarkers, tested the NSCLC signal for innate-pathway enrichment, and examined Results: We found that Conclusions: An approximate model-based component of the ADHD-NSCLC genetic covariance was statistically independent of the measured current-smoking phenotype; pathway and biomarker analyses suggested, but did not establish, an innate immune and inflammatory dimension alongside the 15q25 cholinergic axis.
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