Evidence map›Paper›PMID 42661477›Full record

ArticleTransboundary and emerging diseases2026

Inhibitory Effects of Enoxolone on Porcine Epidemic Diarrhea Virus In Vitro and In Vivo.

Jie Li, Feixiang Zhu, Han Xu, Hongyue Li, Jiang Jin, Muyu Zhu, Junjie Liu, Jun Wang, Yingchun Zhou, Zongyi Bo and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jie LiCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.
Feixiang ZhuCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.
Han XuCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.
Hongyue LiCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.
Jiang JinCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.
Muyu ZhuCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.
Junjie LiuCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.
Jun WangAnhui Provincial Center for Animal Disease Control and Prevention, Hefei 230091, China.
Yingchun ZhouAnhui Provincial Center for Animal Disease Control and Prevention, Hefei 230091, China.
Zongyi BoJoint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China, yzu.edu.cn.
Haixiao ShenCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China, njau.edu.cn.ORCID https://orcid.org/0000-0001-8529-4324
Junfang YanKey Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A&F University, Lin'an 311300, Zhejiang, China, zafu.edu.cn.ORCID https://orcid.org/0009-0000-4021-1695
Yan ChengCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.
Xinyue ChangCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.ORCID https://orcid.org/0000-0001-7027-3889
Xuelan LiuCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.
Xianrui ZhengCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China, ahau.edu.cn.
Wei LiCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.
Zongjun YinCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China, ahau.edu.cn.
Liang LiCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.ORCID https://orcid.org/0000-0003-1002-4228
Pei SunCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, Anhui, China, ahau.edu.cn.ORCID https://orcid.org/0009-0004-6983-2742

Funding

Anhui Agricultural University's Scientific Research Funding Projects for Introducing and Stabling Talents rc392105Anhui Higher Institutions Natural Science Foundation 2025AHGXZK20239Collaborative Innovation Project of Universities in Anhui Province GXXT-2023-059National Natural Science Foundation of China 32202777National Natural Science Foundation of China 32573167Natural Science Foundation of Anhui Province 2208085MC80Natural Science Foundation of Anhui Provincial Education Department 2024AH040083Research Funds of Joint Research Center for Food Nutrition and Health of IHM 2023SJY01Science and Technology Innovation 2030- Major Project 2023ZD0404402-03Special Fund for Anhui Agriculture Research System AHCYJSTX-05-07Special Fund for Anhui Agriculture Research System AHCYJSTX-05-21Youth Project of Natural Science Foundation of Anhui Province 2508085Y019
6 · The paper itself

Abstract

Porcine epidemic diarrhea (PED) is characterized as an acute and highly contagious intestinal ailment induced by the PED virus (PEDV), presenting clinical symptoms such as emesis, diarrhea, and dehydration. The occurrence of PED has imposed a substantial economic burden on the global swine farming industry. The PEDV strain exhibits a proclivity for mutations, and the immune response elicited by traditional vaccines may prove ineffective against the virus. Meanwhile, given concerns about the tolerance to existing drugs. Consequently, there is an urgent necessity to develop novel anti PEDV drugs. As a natural compound, studies have demonstrated that enoxolone possesses multiple pharmacological attributes, encompassing antitumor, antiulcer, antiviral, and anti-inflammatory activities both in vivo and in vitro. In this study, we investigated the antiviral efficacy of enoxolone against PEDV. Enoxolone inhibits the proliferation of PEDV through multiple pathways. Initially, it degrades the nucleocapsid (N) protein via the lysosomal-autophagy pathway. Additionally, in vitro experiments have demonstrated that Enoxolone suppresses the NF-κB signaling pathway activated by PEDV, indicating its anti-inflammatory properties and its ability to inhibit the inflammatory response triggered by PEDV in vitro. Furthermore, in vivo results show that enoxolone effectively alleviates the symptoms and intestinal damage caused by PEDV in piglets. Briefly speaking, our research verifies that enoxolone can inhibit the replication of PEDV both in vivo and in vitro, providing a novel direction for the development of antiviral drugs against PED.

Indexed as

Antiviral AgentsCoronavirus InfectionsPorcine epidemic diarrhea virusSwine DiseasesAnimalsSwineAntiviral Agentsautophagy-lysosome pathwayenoxoloneNF-κB pathwayPEDV

Identifiers

PMID42661477
PMCPMC13522830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.