ArticleLiver international : official journal of the International Association for the Study of the Liver2026
Impact of PD-1 Inhibitor Timing Relative to Locoregional Therapy on Outcomes in uHCC Treated With Lenvatinib-Based Triple Therapy.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Impact of PD-1 Inhibitor Timing Relative to Locoregional Therapy on Outcomes in uHCC Treated With Lenvatinib-Based Triple Therapy.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
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14 authors.
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Abstract
BACKGROUND AND
aimsThe optimal sequencing of programmed cell death protein 1 (PD-1) inhibitors relative to locoregional therapy (LRT) in unresectable hepatocellular carcinoma (uHCC) remains undefined. This study evaluated the impact of PD-1 inhibitor timing on outcomes in patients receiving hepatic arterial infusion chemotherapy (HAIC) or transarterial chemoembolisation (TACE) plus lenvatinib and PD-1 inhibitors.
methodsPatients with initially uHCC who received LRT in combination with lenvatinib and PD-1 inhibitors across six academic centres were stratified by LRT modality (HAIC vs. TACE) and categorised into two groups based on PD-1 inhibitor timing (Pre-LRT PD-1 and Post-LRT PD-1 group). Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method; propensity score matching (PSM) and landmark analyses were applied to mitigate potential biases.
resultsA total of 350 patients were included, with 185 in the HAIC cohort and 165 in the TACE cohort. Pre-LRT PD-1 group was associated with significantly improved OS in the overall population, driven primarily by the HAIC cohort rather than the TACE cohort (34.03 m vs. 30.6 m, p = 0.032); these findings remained consistent after PSM and landmark analyses. Subgroup analyses further supported the survival benefit of Pre-LRT PD-1 initiation. After PSM, Pre-LRT PD-1 was also associated with significantly prolonged PFS in the HAIC cohort. According to RECIST 1.1 criteria, the Pre-LRT PD-1 group showed a higher objective response rate (ORR) (p = 0.002).
conclusionsIn patients with uHCC receiving HAIC combined with lenvatinib and PD-1 inhibitors, initiation of PD-1 inhibitors prior to HAIC is associated with superior survival outcomes.
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