Evidence map›Paper›PMID 42661384›Full record

ReviewMolecular nutrition & food research2026

A Comprehensive Review on Cardioprotective Biological Properties of Crataegus orientalis in Post-COVID-19 Pandemic Cardiovascular Disorders.

Ayman M Mousa, Hamdoon A Mohammed

Abstract readReview
In one paragraph

Review in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ayman M MousaDepartment of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Hamdoon A MohammedDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.

Funding

Saudi National Institute of Health [Saudi NIH] PRI01-2401-QU008-46530391
6 · The paper itself

Abstract

The growing use of herbal medicinal plants like hawthorn is recognized globally as a way to meet the demand for new natural pharmaceuticals with health benefits. The current review provides a comprehensive overview of the phytochemical constituents and heart-protective therapeutic properties of Crataegus orientalis. Despite numerous reviews on the biological properties of the Crataegus genus. C. orientalis has emerged as a promising therapeutic agent in managing the increasing cardiovascular complications that have followed the COVID-19 pandemic. This review highlights the primary cardioprotective biological effects of C. orientalis, including antioxidant, anti-inflammatory, hypolipidemic, antihyperglycemic, antihypertensive, anticoagulant, anti-ischemic, diuretic, and cardiotonic properties, supported by numerous scientific studies in Web of Science, Google Scholar, and PubMed. This updated review provides an overview of the bioactive molecular components of C. orientalis and their cardioprotective mechanisms in cardiac muscle cell biology following the post-COVID-19 Pandemic, exploring its potential as an innovative functional food dietary supplement to enhance plant-derived cardioprotective formulations and its possible health benefits. This study presents a significant challenge for analyzing the active constituents of C. orientalis, which require further research, as they are expected to be promising candidates for developing new approaches to prevent and treat various post-pandemic cardiovascular diseases (CVD).

Indexed as

Cardiotonic AgentsCardiovascular DiseasesCOVID-19CrataegusPlant ExtractsAnimalsAnti-Inflammatory AgentsAntioxidantsCOVID-19 Drug TreatmentHumansPandemicsPhytochemicalsPhytotherapySARS-CoV-2Anti-Inflammatory AgentsAntioxidantsCardiotonic AgentsPhytochemicalsPlant Extractsantioxidantscardiovascular diseasesCrataegus orientalisflavonoidsoxidative stresspandemicspolyphenols

Identifiers

PMID42661384
PMCPMC13522660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.