ArticleCNS neuroscience & therapeutics2026
Dynamic Functional Connectivity Changes in Cortical and Cortico-Striatal Strokes in Mice.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsTo determine how lesion size and location shape longitudinal functional connectivity (FC) changes after stroke.
methodsAdult male mice underwent atlas-based resting-state fMRI at baseline and 1, 2, and 4 weeks after either a small photothrombotic cortical stroke (N = 25) or a larger transient cortico-striatal MCAO stroke (N = 6). FC was quantified across 98 atlas regions, focusing on sensorimotor cortex, striatum, and thalamus, including intra- and inter-hemispheric connectivity matrices and regional seed strength.
resultsCortical stroke caused widespread hyperconnectivity at Weeks 1-2, with about 90% of connections increased, followed by partial normalization by Week 4. This effect declined most strongly in the ischemic hemisphere and remained more sustained contralesionally. In contrast, cortico-striatal stroke induced global hypoconnectivity at Week 1, with more than 90% of connections decreased, a modest and heterogeneous shift toward baseline at Week 2, and widespread decreases persisting at Week 4. A subset of sensorimotor connections showing opposite changes in the two models robustly separated groups at all post-stroke time points. Regional lesion involvement scaled with the magnitude of baseline-referenced FC alterations.
conclusionLesion topography drives distinct longitudinal FC trajectories after stroke and may help define network biomarkers and optimal windows for targeted interventions.
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