Evidence map›Paper›PMID 42661204›Full record

ArticleVeterinary research2026

Type VII secretion system promotes Streptococcus agalactiae virulence through magnesium acquisition and capsule maintenance.

Fengyang Li, Chen Xu, Weiyi Ma, Yong Zhou, Yang Zhou, Yong-An Zhang, Hui Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fengyang LiHubei Hongshan Laboratory; Hainan Research Institute; National Key Laboratory of Agricultural Microbiology; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China.
Chen XuYangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, 430223, Hubei, China.
Weiyi MaHubei Hongshan Laboratory; Hainan Research Institute; National Key Laboratory of Agricultural Microbiology; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China.
Yong ZhouYangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, 430223, Hubei, China.
Yang ZhouHubei Hongshan Laboratory; Hainan Research Institute; National Key Laboratory of Agricultural Microbiology; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China.
Yong-An ZhangHubei Hongshan Laboratory; Hainan Research Institute; National Key Laboratory of Agricultural Microbiology; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China. yonganzhang@mail.hzau.edu.cn.
Hui ZengHubei Hongshan Laboratory; Hainan Research Institute; National Key Laboratory of Agricultural Microbiology; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education; College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China. huizeng@mail.hzau.edu.cn.

Funding

China Agriculture Research System of MOF and MARA CARS-46National Key Research and Development Program of China 2023YFD2400701National Natural Science Foundation of China 32473204the National Key Research and Development Program of China 2023YFD2400704
6 · The paper itself

Abstract

Streptococcus agalactiae, also known as group B Streptococcus (GBS), is a major pathogen causing substantial economic losses in global tilapia aquaculture. The type VII secretion system (T7SS), present in Actinobacteria and Firmicutes, secretes effector proteins implicated in bacterial virulence, yet its functional mechanisms remain poorly defined. Here, we constructed an essC deletion mutant (∆essC) in S. agalactiae strain HN016 to investigate the role of T7SS in virulence. The ∆essC exhibited impaired growth and declined intracellular magnesium ion concentration in THB or magnesium-limited chemically defined medium (1 mM Mg

Indexed as

Bacterial CapsulesFish DiseasesMagnesiumStreptococcal InfectionsStreptococcus agalactiaeType VII Secretion SystemsAnimalsBacterial ProteinsVirulenceBacterial ProteinsMagnesiumType VII Secretion SystemscapsuleMagnesiumStreptococcus agalactiaetype VII secretion system (T7SS)virulence

Identifiers

PMID42661204
PMCPMC13520451

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.