ArticleBMC ophthalmology2026
Correlation between aqueous humour cytokine and imaging biomarker in Central Retinal Vein Occlusion-Macular Edema.
Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aims to examine the relationship between the concentrations of different aqueous humour cytokine and the Central retinal thickness (CRT), the area of the Foveal avascular zone (FAZ) and the vascular density of superficial capillary plexus (SCP-VD) in patients with Central Retinal Vein Occlusion-Macular Edema (CRVO-ME) through a prospective clinical investigation.
methodsA total of 20 cases with 20 eyes were included from Linyi Peoples Hospital. OCT and OCTA were employed to examine a 6 mm × 6 mm region in the macula, acquiring CRT, FAZ area, and SCP-VD data. Aqueous humor samples were collected to measure its Interleukin-6(IL-6),Interleukin-8 (IL-8),Vascular endothelial growth factor (VEGF), Vascular cell adhesion molecule (VCAM), Placental growth factor (PGF), and Monocyte chemoattractant protein-1 (MCP-1) level. The correlation between these values of CRT, FAZ area, and SCP-VD in the affected eye were analyzed using statistical Pearson methods.
resultsThe CRT of the affected eye in CRVO-ME patients was (572.80 ± 186.57) μm; the SCP-VD was (39.73 ± 1.56) %; and the FAZ area was (0.45 ± 0.06) mm
conclusionsThe concentration of intraocular cytokines exhibited a substantial correlation with the macular structure of the macula and the extent of microvascular damage surrounding the macula.
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