Evidence map›Paper›PMID 42661072›Full record

Trial reportNature microbiology2026

Autodissemination stations suppress Aedes notoscriptus mosquitoes and reduce Buruli ulcer risk in urban Australia: a randomized controlled field trial.

Véronique Paris, Andrew H Buultjens, Nicholas Bell, Thomas L Schmidt, Wendy M Bamberg, Michael T Birrell, Finn Romanes, Catarina A Antao, Maria Globan, Caroline Lavender and 11 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Véronique Paris *Pest and Environmental Adaptation Research Group, School of BioSciences, Bio21 Institute, University of Melbourne, Parkville, Victoria, Australia. veronique.paris@unimelb.edu.au.ORCID http://orcid.org/0000-0002-3667-685X
Andrew H Buultjens *Department of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-5984-1328
Nicholas BellPest and Environmental Adaptation Research Group, School of BioSciences, Bio21 Institute, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-2420-6682
Thomas L SchmidtSchool of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales, Australia.ORCID http://orcid.org/0000-0003-4695-075X
Wendy M BambergWestern Public Health Unit, Western Health, St Albans, Victoria, Australia.
Michael T BirrellWestern Public Health Unit, Western Health, St Albans, Victoria, Australia.
Finn RomanesWestern Public Health Unit, Western Health, St Albans, Victoria, Australia.
Catarina A AntaoDepartment of Health, Melbourne, Victoria, Australia.
Maria GlobanDepartment of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.
Caroline LavenderWHO Collaborating Centre for Mycobacterium ulcerans, Mycobacterium Reference Laboratory, Victorian Infectious Diseases Reference Laboratory, Doherty Institute, Melbourne, Victoria, Australia.
Katherine BondDepartment of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.
Sally DougallDepartment of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.
Jake A LaceyDepartment of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-6492-6983
Yichen ZhaiLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Peihong GuoLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Norelle L SherryDepartment of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-7789-8360
Katherine B GibneyWHO Collaborating Centre for Antimicrobial Resistance, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-5851-5339
Jue Tao LimLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID http://orcid.org/0000-0002-2245-0331
Paul D R JohnsonDepartment of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.ORCID http://orcid.org/0000-0001-9873-7163
Timothy P StinearDepartment of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia. tstinear@unimelb.edu.au.ORCID http://orcid.org/0000-0003-0150-123X
Ary A HoffmannPest and Environmental Adaptation Research Group, School of BioSciences, Bio21 Institute, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-9497-7645

Funding

Department of Health | National Health and Medical Research Council (NHMRC) GNT1196396Wellcome TrustWellcome Trust (Wellcome) 226166/Z/22/Z
6 · The paper itself

Abstract

Aedes notoscriptus are mosquito vectors implicated in transmission of Mycobacterium ulcerans. This bacterium causes a destructive infection of skin and soft tissue called Buruli ulcer. Here we ran a randomized controlled trial in an urban Buruli ulcer endemic area in Melbourne, Australia to test whether autodissemination mosquito control stations, containing pyriproxyfen (larvicide) and Beauveria bassiana (entomopathogenic fungus), suppress Ae. notoscriptus populations. Six geographic areas each received 100 autodissemination stations for 8 weeks, and six control areas received no stations between 25 January 2024 and 21 March 2024. The primary outcome measure was mosquito population numbers. After the trial, there was a 70% average reduction in mosquito egg counts among the six intervention areas compared to control areas (P = 0.0076). In an ad hoc analysis, we then explored human Buruli ulcer notifications in treatment and control areas. After accounting for the 4.8-month mean incubation period, there was an 83% reduction in infection likelihood coinciding with peak intervention effect (intervention zones 1 case, control zones 6 cases, incidence ratio rate 0.167, 95% CI 0.0026-1.054, P = 0.047). The effect was not observed during the same time period in the year previous or following 2024, when no interventions were undertaken. A strong correlation (R

Indexed as

AedesBuruli UlcerMosquito ControlMosquito VectorsAnimalsBeauveriaFemaleHumansInsecticidesMycobacterium ulceransPyridinesVictoriaInsecticidesPyridinespyriproxyfen

Identifiers

PMID42661072
PMCPMC13524796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.