Evidence map›Paper›PMID 42661046›Full record

ReviewNature reviews. Molecular cell biology2026

Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease.

Carsten Janke, Anna Akhmanova, Francesca Bartolini, Satish Bodakuntla, Filippo Del Bene, Virginie Hamel, Timothy J Mitchison, Thomas Müller-Reichert, François Nédélec, Eva Nogales and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Carsten JankeInstitut Curie, PSL Research University, CNRS UMR 3348, INSERM U1368, Orsay, France. Carsten.Janke@curie.fr.ORCID http://orcid.org/0000-0001-7053-2000
Anna AkhmanovaCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-9048-8614
Francesca BartoliniDepartment of Pathology & Cell Biology, Columbia University, New York, NY, USA.
Satish BodakuntlaLaboratory of Structural Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Filippo Del BeneSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.ORCID http://orcid.org/0000-0001-8551-2846
Virginie HamelDepartment of Molecular and Cellular Biology, Faculty of Sciences, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-5092-2343
Timothy J MitchisonDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Thomas Müller-ReichertExperimental Center, Carl Gustav Carus Faculty of Medicine, Dresden University of Technology, Dresden, Germany.ORCID http://orcid.org/0000-0003-0203-1436
François NédélecSainsbury Laboratory, Cambridge University, Cambridge, UK.
Eva NogalesMolecular and Cell Biology Department, Institute for Quantitative Biomedicine, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-9816-3681
Gaia PiginoHuman Technopole (HT), Structural Biology Research Centre, Milan, Italy.ORCID http://orcid.org/0000-0002-2295-9568
Antonina Roll-MecakCell Biology and Biophysics Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Giampietro SchiavoDepartment of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0002-4319-8745
Thomas SurreyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0001-9082-1870
Zdenek LanskyInstitute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microtubules are well-researched components of the cytoskeleton, yet we lack a holistic understanding that bridges molecular and cellular details with the broader functions of the microtubule cytoskeleton in development, ageing and disease. For example, how microtubule properties and functions are affected by tubulin post-translational modifications, disease-related mutations or variation of the microtubule lattice remains unexplored. In this Roadmap, we argue that integrating various experimental and theoretical approaches to bridge different spatial and temporal scales will offer new opportunities for gaining insights into essential cellular mechanisms and physiology, eventually revealing how microtubule dysfunction can lead to a broad spectrum of human diseases. Built on the current state of the art in the microtubule field, our Roadmap highlights future opportunities and challenges and proposes ways to tackle them. Given the many fundamental questions remaining to be answered, the microtubule cytoskeleton will continue to inspire scientists as it has been doing for decades.

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.