ArticleCommunications chemistry2026
Photocatalytic proximity labeling for the identification of G-quadruplex DNA-interacting proteins.
Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- A subcellular selective APEX2-based proximity labeling used for identifying mitochondrial G-quadruplex DNA binding proteins.Nucleic acids research · 2025Article
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Authors and funding
18 authors.
Funding
Abstract
DNA-protein interactions play an essential role in fundamental cellular biological processes. Herein, we report a photocatalytic proximity labeling approach for the broad screening of G-quadruplex (G4)-interacting proteins (G4IPs) using human telomere G4 DNA modified with a photocatalyst (Ruthenium complex or BODIPY). We confirmed efficient labeling of unwinding protein 1 (UP1), a model of G4-interacting protein, with 1-methyl-4-arylurazole (MAUra) as a labeling reagent under blue light irradiation. We applied this labeling approach to nuclear extract proteins and identified labeled proteins using quantitative proteomics analysis. Numerous unknown G4 binding protein candidates were identified. Notably, the hexokinase-1 (HK1) protein was identified as a G4IP, and its selective binding toward G4 DNA was confirmed. This finding could be used to highlight the essential subcellular G4-mediated functions of HK1. The proposed labeling approach is a promising tool for investigating the protein interactions of the higher-order structural motifs and functional nucleic acids.
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