ReviewNature reviews. Immunology2026
Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease.
Review in Nature reviews. Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
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Abstract
Epigenetic regulation orchestrates B cell development, lineage commitment, subset differentiation and activation, and is equally central to the maintenance of B cell self-tolerance. Disruption of epigenetic homeostasis at successive tolerance checkpoints - from central tolerance in the bone marrow to peripheral tolerance at germinal centre and extrafollicular stages - can lead to the emergence of autoreactive B cells and the production of autoantibodies in systemic autoimmune diseases. In this Review, we describe the molecular mechanisms by which multiple epigenetic layers - encompassing DNA methylation, histone modification, chromatin remodelling, non-coding RNA regulation and RNA modification - collectively regulate normal B cell function and, when dysregulated, contribute to autoimmune pathogenesis. We examine how specific epigenetic axes, including microRNA-PI3K signalling, DNA demethylation-histone deacetylation balance and chromosome-linked innate immune receptor control, underpin tolerance checkpoint failure and B cell dysfunction in autoimmune disease. Finally, we discuss emerging epigenetic-targeted therapeutic strategies and highlight future research directions aimed at modulating disease-relevant B cell programmes in systemic autoimmunity.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.