Evidence map›Paper›PMID 42660962›Full record

ReviewNPJ Parkinson's disease2026

Biological heterogeneity in Parkinson's disease: implications for MRI-based patient stratification.

Marta M Pokotylo, Norbert Brüggemann, Jannik Prasuhn

Abstract readReview
In one paragraph

Review in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marta M PokotyloSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Norbert BrüggemannSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Jannik PrasuhnSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. jannik.prasuhn@uksh.de.

Funding

Else-Kröner-Fresenius Stiftung 2023_EKEA.168
6 · The paper itself

Abstract

Parkinson's disease is increasingly recognized as a heterogeneous syndrome characterized by diverse pathological processes and clinical manifestations. Here, we propose a multidimensional framework to assess this heterogeneity, with each dimension potentially captured using advanced magnetic resonance imaging techniques. The framework comprises dominant pathological processes, spatial distribution patterns of pathology across brain regions, propagation architecture, temporal dynamics of disease progression, co-pathology burden, and system response and resilience mechanisms.

Identifiers

PMID42660962
PMCPMC13522543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.