ArticleNature communications2026
CD97/ADGRE5 attenuates the induction of adaptive type 2 immune responses in allergic asthma.
Gabriela Aust, Anna-Lena Hoh, Jehan Alladina, Neal P Smith, Florian Höhna, Bingyu Wang, Christiane Kerner, Marita Wagner, Knut Krohn, Arkadiusz Pierzchalski and 9 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
19 authors.
Gabriela Aust *Research Laboratories of the Department of Visceral, Transplantation, Vascular, and Thoracic Surgery, Leipzig University and University Hospital Leipzig, Leipzig, Germany.
Anna-Lena Hoh *Research Laboratories of the Department of Visceral, Transplantation, Vascular, and Thoracic Surgery, Leipzig University and University Hospital Leipzig, Leipzig, Germany.ORCID 0009-0002-1704-2947 Jehan AlladinaDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0136-6859 Neal P SmithCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1394-3158 Florian HöhnaResearch Laboratories of the Department of Visceral, Transplantation, Vascular, and Thoracic Surgery, Leipzig University and University Hospital Leipzig, Leipzig, Germany.
Bingyu WangDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.ORCID 0009-0005-1222-3185 Christiane KernerResearch Laboratories of the Department of Visceral, Transplantation, Vascular, and Thoracic Surgery, Leipzig University and University Hospital Leipzig, Leipzig, Germany.
Marita WagnerDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.
Arkadiusz PierzchalskiDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.
Nele HäusslerResearch Laboratories of the Department of Visceral, Transplantation, Vascular, and Thoracic Surgery, Leipzig University and University Hospital Leipzig, Leipzig, Germany.
Alexandra Chloe VillaniCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7461-0408 Josalyn L ChoDivision of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-0367-4495 Benjamin D MedoffDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2558-0449 Ana C ZenclussenDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.ORCID 0000-0003-3544-4552 Matthias SteinertResearch Laboratories of the Department of Visceral, Transplantation, Vascular, and Thoracic Surgery, Leipzig University and University Hospital Leipzig, Leipzig, Germany.
Jörg HamannDepartment of Experimental Immunology, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam University Medical Center, Amsterdam, The Netherlands.ORCID 0000-0002-9448-1727 Marianne Quaas *Research Laboratories of the Department of Visceral, Transplantation, Vascular, and Thoracic Surgery, Leipzig University and University Hospital Leipzig, Leipzig, Germany.ORCID 0000-0002-2781-1968 Tobias Polte *Department of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany. tobias.polte@ufz.de.ORCID 0009-0006-6055-7005 Funding
Institutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7MDeutsche Forschungsgemeinschaft (German Research Foundation) PO731/8-19NCATS NIH HHS KL2 TR002542NCI NIH HHS DP2-CA247831
6 · The paper itselfAbstract
Allergic asthma results from an uncontrolled type 2 immune response to inhaled allergens. Here, we investigate the function of CD97/ADGRE5, expressed in mouse and human immune and lung epithelial cells, in this disease. Female Cd97
Indexed as
Adaptive ImmunityAntigens, CDAsthmaAllergensAnimalsCytokinesDendritic CellsFemaleHumansLungMiceMice, Inbred C57BLMice, KnockoutAllergensAntigens, CDCytokines
Identifiers
PMID42660929
PMCPMC13522487
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