Evidence map›Paper›PMID 42660912›Full record

ArticleNature communications2026

Longitudinal characterization of mosaic chromosomal alterations identifies factors influencing clonal dynamics of leukocytes.

Rebecca L Kelly, Derek W Brown, Weiyin Zhou, Aubrey K Hubbard, Corey D Young, Kara M Barnao, Alyssa Klein, Diptavo Dutta, Aurélie Vogt, Jia Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rebecca L KellyCancer Prevention Fellowship Program, National Cancer Institute, NIH, Rockville, MD, USA.ORCID 0009-0009-4378-737X
Derek W BrownCancer Prevention Fellowship Program, National Cancer Institute, NIH, Rockville, MD, USA.ORCID 0000-0001-8393-1713
Weiyin ZhouDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.ORCID 0000-0002-0467-3064
Aubrey K HubbardDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.ORCID 0000-0003-4052-1110
Corey D YoungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.ORCID 0000-0003-1841-3527
Kara M BarnaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.ORCID 0009-0006-2308-4464
Alyssa KleinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.ORCID 0000-0003-3763-5731
Diptavo DuttaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.ORCID 0000-0002-6634-9040
Aurélie VogtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.
Jia LiuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.
Jiahui WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.ORCID 0000-0002-4440-3368
Neal D FreedmanDivision of Cancer Control and Population Sciences, National Cancer Institute, NIH, Rockville, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.ORCID 0000-0002-2324-3393
Paul S AlbertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA. mitchell.machiela@nih.gov.ORCID 0000-0001-6538-9705

Funding

Intramural Research Program of the National Institutes of Health (NIH)
6 · The paper itself

Abstract

Characterizing the variation in clonal trajectory of age-related mosaic chromosomal alterations (mCAs) in circulating leukocytes can identify etiologic factors influencing clonal expansion and hematologic malignancy risk. Here we scan whole blood-derived DNA of 56,324 participants from the Prostate, Lung, Colorectal, Ovarian Cancer Screening Study for mCAs and characterize 1746 longitudinal mCAs. Cross-sectional mCA clonal fraction only moderately correlates with clonal expansion rate, highlighting the utility of serial sampling for evaluating clonal trajectory. The strongest contributor to clonal expansion is genomic location of an mCA with participant age, smoking status, and co-occurring mCA types also modifying expansion rates. Germline susceptibility to mosaic Y or X loss is not associated with expansion rate, supporting independent mechanisms governing generation and expansion. Autosomal mCAs previously associated with hematologic malignancies have the highest rates of expansion, especially myeloid malignancy-associated mCAs, underscoring the importance of tracing mCA clonal dynamics for evaluating hematologic cancer risk.

Indexed as

Chromosome AberrationsHematologic NeoplasmsLeukocytesMosaicismCross-Sectional StudiesFemaleHumansLongitudinal StudiesMale

Identifiers

PMID42660912
PMCPMC13522525

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