ArticleNature communications2026
Dynamic remodeling of the pancreas immune landscape in obesity.
Alexey Koshkin, Kranthi Kiran Kishore Tanagala, Anna Eichinger, Michael Chait, Aoife Young, Shanila Shakil, Junichi Yoshikawa, Yosuke Sakamoto, Steven B Wells, Ladan Fazlollahi and 4 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors.
Alexey KoshkinDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Kranthi Kiran Kishore TanagalaDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Michael ChaitDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Aoife YoungDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Shanila ShakilDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Junichi YoshikawaDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-1490-1558 Yosuke SakamotoDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Steven B WellsDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-5428-0683 Ladan FazlollahiDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Xiaojuan ChenColumbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Donna L FarberDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-8236-9183 Stuart P WeisbergDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. spw13@cumc.columbia.edu.ORCID 0000-0002-8698-5976 Funding
Transcriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3MTissue Resident Immune Cells in Human Pancreas.K08DK122130 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WEISBERG, STUART P · 2019 to 2023
$827kFive-laser Aurora spectral flow cytometerS10OD030282 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CREUSOT, REMI J · 2022 to 2022
$361kMechanisms of pancreatic inflammation in obesityR03DK140421 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WEISBERG, STUART P · 2025 to 2025
$247kDeutsche Forschungsgemeinschaft (German Research Foundation) EI1185/1-1Gerstner Family Foundation Louis V. Gerstner, Jr Scholars ProgramNIAID NIH HHS P01 AI106697NIDDK NIH HHS K08 DK122130NIDDK NIH HHS R03 DK140421NIH HHS S10 OD030282U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) P01 AI106697U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) S10OD030282U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK122130U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R03 1R03DK140421-01A1
6 · The paper itselfAbstract
Obesity is a known risk factor for diseases of the pancreas, including diabetes, pancreatic cancer and pancreatitis, but mechanisms remain unclear. Here we show by spatial, transcriptomic and functional profiling of human pancreatic immune cells from obese and non-obese organ donors that obesity profoundly impacts pancreatic immune homeostasis. Obesity is associated with higher density of tissue resident memory T-cells (TRM) in the exocrine pancreas which are characterized by high cytotoxic functions, and aggregate around macrophages. Single cell sequencing of pancreatic macrophages distinguishes two main subsets - FOLR2 + CD11c- foetal-derived macrophages with pro-repair and immunoregulatory function and FOLR2- CD11c+ lipid-associated macrophages with greater T-cell interactions and pro-inflammatory function. In obesity, the pancreatic macrophage landscape shifts to lower predominance of FOLR2 + CD11c- macrophages and expansion of FOLR2- CD11c+ macrophages, which interact selectively with the TRM and inflamed exocrine epithelium. Together, these results identify macrophage-T cell circuits and immune epithelial interactions that might lead to chronic pancreatic inflammation in obesity and might contribute to obesity-related pancreatic diseases.
Indexed as
MacrophagesObesityPancreasAnimalsCD11c AntigenFemaleHumansMaleMemory T CellsMiceCD11c Antigen
Identifiers
PMID42660905
PMCPMC13521922
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