ArticleEmerging infectious diseases2026
Posttuberculosis Consequences on Tuberculosis Prevention Effectiveness and Cost-effectiveness among New Immigrants, Canada.
Article in Emerging infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Cost-effectiveness analyses of tuberculosis (TB) preventive treatment rarely consider long-term TB consequences. We examined how long-term TB consequences influence the effectiveness and cost-effectiveness of TB prevention among persons who immigrate to Canada. By using a Markov microsimulation model of 400,000 persons immigrating to Canada in 2025, we compared current postarrival TB infection screening levels (0.5%) with a screening level of 68% among new immigrants. Modelling scenarios included acute TB consequences and long-term TB-related death, illness, and healthcare costs (25-year horizon, 1.5% discount rate). Including long-term TB-related consequences increased the estimated TB-related quality-adjusted life years (QALYs) lost by 2.1-fold (95% uncertainty range 1.7-2.5-fold). When long-term TB-related consequences were included, estimated QALYs gained from expanded screening increased 2.4-fold (95% uncertainty range 1.6-4.4-fold), reducing the cost per QALY from $235,088 to $100,742 CAD. Ignoring long-term TB consequences substantially underestimates the effectiveness and cost-effectiveness of preventive interventions; such consequences should be incorporated into future evaluations.
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