Evidence map›Paper›PMID 42660740›Full record

ReviewTrends in biotechnology2026

Organ-on-chip bridging musculoskeletal disease modeling and precision therapeutic discovery.

Qi Gao, Max L Lee, Meagan Makarczyk, Simon K-H Chow, Bruce A Bunnell, Hang Lin, Stuart B Goodman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qi GaoOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Max L LeeOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Meagan MakarczykCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Simon K-H ChowOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Bruce A BunnellDepartment of Biomedical and Translational Sciences, Carle Illinois College of Medicine, University of Illinois, Urbana, IL 61801, USA.
Hang LinCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Stuart B GoodmanOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA. Electronic address: goodbone@stanford.edu.

Funding

Tissue Chip Modeling of Synovial Joint Pathologies: Effects of Inflammation and Adipose-Mediated Diabetic ComplicationsUG3TR002136 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TUAN, ROCKY S · 2017 to 2018
$2.5M
Defining the unique capacity of the miniature joint model for investigating the role of adipose tissue and its impacts on osteoarthritisR01AR082386 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bruce A. Bunnell, STUART B GOODMAN · 2024 to 2026
$1.9M
Neurophysiology of Weakness and Exercise in Rotator Cuff TendinopathyR01AR063713 · NIAMS · UNIVERSITY OF OREGON · PI KARDUNA, ANDREW ROBERT · 2014 to 2018
$1.7M
Repurposing FDA-approved drugs for the treatment of osteoarthritis using high-throughput screening in microphysiological modelsR01AR084472 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bruce A. Bunnell, STUART B GOODMAN · 2024 to 2026
$1.6M
Customized MSCs to Enhance Healing of Bone DefectsR01AR073145 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2018 to 2021
$1.4M
NCATS NIH HHS UG3 TR002136NIAMS NIH HHS R01 AR063713NIAMS NIH HHS R01 AR073145NIAMS NIH HHS R01 AR082386NIAMS NIH HHS R01 AR084472
6 · The paper itself

Abstract

Musculoskeletal (MSK) disorders remain a leading cause of disability, yet effective disease-modifying therapies are limited by poor translational relevance of conventional models. Organ-on-chip (OoC) technologies have emerged as promising platforms for disease modeling and therapeutic discovery. This review highlights recent advances in patient-derived and induced pluripotent stem cell-based OoC systems, multicellular tissue engineering, biomechanical and immune integration, real-time sensing, and data-driven analytics that enhance physiological relevance and predictive capability. We further discuss automated high-throughput screening and machine learning approaches for scalable drug testing and personalized therapeutic prediction. Finally, we address challenges including reproducibility, vascularization, and standardization, and outline a future roadmap toward precision medicine through intelligent OoC platforms and patient-specific digital twins.

Indexed as

musculoskeletal diseaseorgan-on-chipprecision medicine

Identifiers

PMID42660740
PMCPMC13523067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.