Evidence map›Paper›PMID 42660646›Full record

ArticleChemMedChem2026

A New Sustainable Approach to Antibiotic Resistance: Development of bis-Quaternary Ammonium Salts From 2,4,6-Trichloro-1,3,5-Triazine.

Rachele Rampazzo, Arianna De Luca, Manuela Facchin, Patrizio Raffa, Andrea Gattolin, Valentina Beghetto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachele RampazzoDepartment of Molecular Sciences and Nanosystems, Ca' Foscari University Venice, Venice, Italy.ORCID https://orcid.org/0009-0007-2964-7974
Arianna De LucaDepartment of Molecular Sciences and Nanosystems, Ca' Foscari University Venice, Venice, Italy.ORCID https://orcid.org/0009-0006-2262-6532
Manuela FacchinCrossing S.r.l., Treviso, Italy.ORCID https://orcid.org/0000-0002-3528-941X
Patrizio RaffaDepartment of Chemical Engineering - Product Technology, University of Groningen - FSE - ENTEG, Groningen, Netherlands.ORCID https://orcid.org/0000-0003-0738-3393
Andrea GattolinChimicambiente Srl, Vicenza, Italy.ORCID https://orcid.org/0009-0008-8394-3026
Valentina BeghettoDepartment of Molecular Sciences and Nanosystems, Ca' Foscari University Venice, Venice, Italy.ORCID https://orcid.org/0000-0001-8799-210X

Funding

National Recovery and Resilience Plan (PNRR), for the 39th PhD cycle "National Interest PhD Program in Design for Made in Italy: Identity, Innovation,and Sustainability", administrative headquarter University of Campania "Luigi Vanvitelli", Caserta (Italy)
6 · The paper itself

Abstract

The development of highly effective antibiotics and antimicrobials over the centuries has greatly improved human life. However, the irresponsible use of these substances and their release into the environment have led to the emergence of resistant microorganisms. Quaternary ammonium salts (QAS), due to their high efficacy as antibacterial agents and their wide spectrum of activity as disinfectants and antiseptics, represent a possibility to avoid antibiotic resistance. In this work, new bis-cationic QAS, having as common precursor 2,4,6-trichloro-1,3,5-triazine, were synthetized showing high antimicrobial properties (bis-TQAS). The compounds obtained were characterized by

Indexed as

Anti-Bacterial AgentsQuaternary Ammonium CompoundsTriazinesDose-Response Relationship, DrugEscherichia coliKlebsiella pneumoniaeListeria monocytogenesMicrobial Sensitivity TestsMolecular StructureSaltsStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsQuaternary Ammonium CompoundsSaltsTriazinesantimicrobial agentslow toxicity antimicrobialsQASquaternary ammonium saltstriazine

Identifiers

PMID42660646
PMCPMC13521741

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.