Evidence map›Paper›PMID 42660452›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2026

Functional brain network correlates of pubertal timing and depressive symptoms in preadolescence.

Athanasia Metoki, Benjamin P Kay, Roselyne J Chauvin, Samuel R Krimmel, Anxu Wang, Philip N Cho, Julia Monk, Noah J Baden, Kristen M Scheidter, Scott Marek and 4 more

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Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Athanasia MetokiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: athanasia.metoki@pennmedicine.upenn.edu.
Benjamin P KayDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St Louis, MO, 63110, USA.
Roselyne J ChauvinDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Samuel R KrimmelDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Anxu WangDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Philip N ChoDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Julia MonkDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Noah J BadenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Kristen M ScheidterDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Scott MarekMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Timothy O LaumannDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Evan M GordonAllied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St Louis, MO, 63110, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Nico U F DosenbachDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St Louis, MO, 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, South Korea; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 63110, USA; Program in Occupational Therapy, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Deanna M BarchMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychological & Brain Sciences, Washington University, St. Louis, MO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVariation in pubertal maturation relative to same-age, same-sex peers (pubertal timing) has been linked to increased risk for depressive symptoms during adolescence. This developmental period is also characterized by substantial reorganization of functional brain networks. However, how pubertal timing relates to resting-state functional connectivity (rsFC) changes and depression risk remains unclear.

methodsWe examined pubertal timing and rsFC associations in 9-11-year-old preadolescents from the Adolescent Brain Cognitive Development (ABCD) Study. Pubertal timing was estimated using a puberty age gap approach based on parent-reported physical development. Linear mixed-effects and Bayesian multilevel models were used to assess cross-sectional and longitudinal associations between pubertal timing and rsFC across large-scale functional brain networks. We also tested whether rsFC differences explained associations between pubertal timing and later depressive symptoms.

resultsEarlier pubertal timing was associated with heterogeneous rsFC patterns, with stronger and more widespread effects in females. Earlier pubertal timing was associated with rsFC increases and decreases across sensory-motor and association networks in females, whereas in males, associations were more limited and localized to sensorimotor and cerebellar systems. Longitudinally, earlier pubertal timing in females predicted reductions in rsFC at the 2-year follow-up, with no significant associations in males. rsFC differences did not explain the pubertal timing and later depressive symptoms association.

conclusionsPubertal timing is associated with sex-specific patterns of brain functional connectivity during early adolescence, with greater heterogeneity and broader network involvement in females. These findings suggest that pubertal maturation contributes to early reorganization of functional brain networks, although these changes did not explain subsequent depressive symptoms.

Indexed as

brain network organizationdepressionearly adolescencePubertal timingresting-state functional connectivity

Identifiers

PMID42660452

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.