Evidence map›Paper›PMID 42660368›Full record

ArticleRespiratory medicine2026

Mitochondrial antioxidant therapy fails to improve obese asthma outcomes.

Anne E Dixon, Olivia J Garrow, Peter Callas, Carolyn Morris, Jason Ht Bates, Francesca Martin, Savannah Barbieri, Maggie Higdon, Vikas Anathy, Loretta G Que

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anne E DixonLarner College of Medicine, University of Vermont, University of Vermont Medical Center, 110 Colchester Avenue, Burlington, VT, 05401, USA. Electronic address: anne.dixon@uvmhealth.org.
Olivia J GarrowLarner College of Medicine, University of Vermont, University of Vermont Medical Center, 110 Colchester Avenue, Burlington, VT, 05401, USA. Electronic address: olivia.garrow@uvm.edu.
Peter CallasLarner College of Medicine, University of Vermont, University of Vermont Medical Center, 110 Colchester Avenue, Burlington, VT, 05401, USA. Electronic address: peter.callas@uvm.edu.
Carolyn MorrisLarner College of Medicine, University of Vermont, University of Vermont Medical Center, 110 Colchester Avenue, Burlington, VT, 05401, USA. Electronic address: carolyn.morris@uvm.edu.
Jason Ht BatesLarner College of Medicine, University of Vermont, University of Vermont Medical Center, 110 Colchester Avenue, Burlington, VT, 05401, USA. Electronic address: Jason.bates@uvm.edu.
Francesca MartinLarner College of Medicine, University of Vermont, University of Vermont Medical Center, 110 Colchester Avenue, Burlington, VT, 05401, USA. Electronic address: frankiekamartin@gmail.com.
Savannah BarbieriDepartment of Medicine, Duke University, PO Box 2629 DUMC, Rm 279 MSRB1, Research Dr., Durham, NC, 27710, USA. Electronic address: savannah.barbieri@duke.edu.
Maggie HigdonDepartment of Medicine, Duke University, PO Box 2629 DUMC, Rm 279 MSRB1, Research Dr., Durham, NC, 27710, USA. Electronic address: maggie.higdon@duke.edu.
Vikas AnathyLarner College of Medicine, University of Vermont, University of Vermont Medical Center, 110 Colchester Avenue, Burlington, VT, 05401, USA. Electronic address: vikas.anathy@uvm.edu.
Loretta G QueDepartment of Medicine, Duke University, PO Box 2629 DUMC, Rm 279 MSRB1, Research Dr., Durham, NC, 27710, USA. Electronic address: loretta.que@duke.edu.

Funding

Mitochondrial Redox Perturbations in Obese Allergic AsthmaR01HL136917 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS, DIXON, ANNE E · 2018 to 2022
$3.6M
NHLBI NIH HHS R01 HL136917
6 · The paper itself

Abstract

backgroundObesity is associated with poorly controlled asthma. One reason for this may be the increased mitochondrial oxidative stress in obese asthma. Indeed, targeting oxidative stress reduces airway reactivity in animal models. The purpose of this trial was to investigate the potential efficacy of the mitochondrial-targeted antioxidant MitoQuinone (MitoQ) for the treatment of poorly controlled asthma in people with obesity.

methodsA twelve week, randomized, double-masked, placebo-controlled trial of 40 mg MitoQ versus placebo in adults with obesity and poorly controlled asthma was performed. The primary outcome was change in airway reactivity, with secondary outcomes of change in asthma control, quality of life, and lung function.

resultsTwenty participants were randomized to MitoQ, 18 to placebo. After 12 weeks, there was no difference in change in airway reactivity to methacholine (provocative dose producing a 20% decrease in FEV

conclusionMitoQ was well tolerated but did not improve airway reactivity, asthma control, or lung function. Targeting oxidative stress in people with obesity and poorly controlled asthma with MitoQ is unlikely to be efficacious for the treatment of asthma.

Indexed as

Airway reactivityAntioxidantsAsthma controlMitochondrial dysfunctionOxidative stressQuality of lifeRandomized controlled trial

Identifiers

PMID42660368
PMCPMC13618691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.