Evidence map›Paper›PMID 42660211›Full record

ArticleActa biomaterialia2026

Matrix metalloproteinase-mediated degradation governs angioarchitecture within poly(ethylene Glycol) hydrogels.

Kevin C Ling, Alyson March, Yingjie Wu, Annika Deans, Jordan Jones, E Thomas Pashuck, Danielle S W Benoit

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kevin C LingUniversity of Rochester, Department of Biomedical Engineering, Rochester, NY, USA; University of Rochester Medical Center, Center for Musculoskeletal Research, Rochester, NY, USA.
Alyson MarchUniversity of Rochester, Department of Biomedical Engineering, Rochester, NY, USA; University of Rochester Medical Center, Center for Musculoskeletal Research, Rochester, NY, USA.
Yingjie WuLehigh University, Department of Bioengineering, Bethlehem, PA, USA.
Annika DeansUniversity of Rochester, Department of Biomedical Engineering, Rochester, NY, USA.
Jordan JonesUniversity of Rochester, Department of Biomedical Engineering, Rochester, NY, USA.
E Thomas PashuckLehigh University, Department of Bioengineering, Bethlehem, PA, USA.
Danielle S W BenoitUniversity of Rochester, Department of Biomedical Engineering, Rochester, NY, USA; University of Rochester Medical Center, Center for Musculoskeletal Research, Rochester, NY, USA; University of Oregon, Department of Bioengineering, Eugene, OR, USA. Electronic address: dbenoit@oregon.edu.

Funding

Tissue Engineering Strategies to Revitalize Bone AllograftsR01AR064200 · NIAMS · UNIVERSITY OF ROCHESTER · PI Danielle S. Benoit · 2013 to 2026
$4.0M
Engineered salivary gland tissue chips (Administrative Supplement)UH3DE027695 · NIDCR · UNIVERSITY OF ROCHESTER · PI BENOIT, DANIELLE S., DELOUISE, LISA A · 2019 to 2021
$3.0M
Using hiPSCs to develop physiologically-relevant outer retina tissue mimeticsR01EY033192 · NEI · UNIVERSITY OF ROCHESTER · PI BENOIT, DANIELLE S., SINGH, RUCHIRA · 2022 to 2024
$1.7M
hiPSC-derived tissue mimetics of the retina blood barrierR21EY030817 · NEI · UNIVERSITY OF ROCHESTER · PI BENOIT, DANIELLE S., SINGH, RUCHIRA · 2020 to 2021
$417k
Designing Hydrogels that Recapitulate Physiological Cell-Matrix AdhesionsR03EB036263 · NIBIB · LEHIGH UNIVERSITY · PI PASHUCK, EUGENE THOMAS · 2024 to 2025
$144k
NEI NIH HHS R01 EY033192NEI NIH HHS R21 EY030817NIAMS NIH HHS R01 AR064200NIBIB NIH HHS R03 EB036263NIDCR NIH HHS UH3 DE027695
6 · The paper itself

Abstract

Current tissue engineering strategies struggle to recapitulate the full diversity of tissue-specific vascular niches. Here, matrix metalloproteinase (MMP)-degradable poly(ethylene glycol) (PEG) hydrogels are used to define design principles governing vascular morphogenesis. Vasculogenesis was modeled by encapsulating human umbilical vein endothelial cells (HUVECs) in PEG hydrogels co-cultured with human mesenchymal stem cells (hMSCs), enabling the formation of 3D vessel networks over two weeks. Angiogenesis was modeled by entrapping HUVEC-hMSC spheroids within PEG hydrogels and assessing endothelial sprouting behavior. In parallel, comparative kinetic parameters for peptide degradation were calculated for vasculogenic (k

Indexed as

AngiogenesisHuman Umbilical Vein Endothelial CellsHydrogelsMatrix MetalloproteinasesMesenchymal Stem CellsNeovascularization, PhysiologicPolyethylene GlycolsHumansPeptidesProteolysisHydrogelsMatrix MetalloproteinasesPeptidesPolyethylene GlycolsAngiogenesisEngineered extracellular matrix (eECM)Microvascular morphogenesisMMP-degradable PEG hydrogelsVasculogenesis

Identifiers

PMID42660211
PMCPMC13618071

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.