Evidence map›Paper›PMID 42660120›Full record

ArticleStem cell reports2026

Generation of effector CD4

Julian Amirault, Dar Heinze, Mengwei Yang, Charles M Kerr, Pushpinder S Bawa, Laura Polanco, Gabriel M Sgambettera, Feiya Wang, Anna C Belkina, Jennifer E Snyder-Cappione and 1 more

Abstract read
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Efficient Generation of Functional TCRαβbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julian AmiraultCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA.
Dar HeinzeCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA.
Mengwei YangCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA.
Charles M KerrCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA.
Pushpinder S BawaCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA.
Laura PolancoDepartment of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Gabriel M SgambetteraCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA.
Feiya WangCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA.
Anna C BelkinaDepartment of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA; Flow Cytometry Core Facility, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Jennifer E Snyder-CappioneDepartment of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Gustavo MostoslavskyCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA; Department of Medicine, Section of Gastroenterology at Boston University and Boston Medical Center, Boston, MA, USA. Electronic address: gmostosl@bu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Off-the-shelf T cell therapies could be transformative in chimeric antigen receptor (CAR) therapies for cancers and treatment of chronic inflammatory diseases. However, challenges remain in generating CD4

Indexed as

CD4-Positive T-LymphocytesInduced Pluripotent Stem CellsCell DifferentiationCytokinesHumansCytokinesCD4helper T celliPSClymphocyte

Identifiers

PMID42660120
PMCPMC13555550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.