Evidence map›Paper›PMID 42660115›Full record

ArticleStructure (London, England : 1993)2026

γ-glutamyl carboxylase inhibition by Anisindione.

Ning Zhou, Rong Wang, Baozhi Chen, Jie Li, Jian-Ke Tie, Fangyu Liu, Xiaofeng Qi

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ning ZhouDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Rong WangDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Baozhi ChenDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jie LiDepartment of Molecular Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jian-Ke TieDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Fangyu LiuDepartment of Molecular Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Xiaofeng QiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: xiaofeng.qi@utsouthwestern.edu.

Funding

Structural and Functional Investigations on Cholesterol Signaling and MetabolismR35GM149533 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Xiaochun Li · 2023 to 2026
$1.9M
Structure and Mechanisms of Mitochondrial Pyruvate Carrier (MPC)R35GM162146 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Xiaofeng Qi · 2026 to 2026
$457k
NIGMS NIH HHS R35 GM149533NIGMS NIH HHS R35 GM162146
6 · The paper itself

Abstract

The maturation of key coagulation factors requires γ-carboxylation catalyzed by γ-glutamyl carboxylase (GGCX), in which vitamin K hydroquinone (VKH

Indexed as

Carbon-Carbon LigasesEnzyme InhibitorsBinding SitesCryoelectron MicroscopyHumansMolecular Docking SimulationProtein BindingVitamin KVitamin K Epoxide ReductasesCarbon-Carbon LigasesEnzyme Inhibitorsglutamyl carboxylaseVitamin KVitamin K Epoxide ReductasesanisindionecoagulationGGCXvitamin Kvitamin K antagonist

Identifiers

PMID42660115
PMCPMC13591496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.