Evidence map›Paper›PMID 42659517›Full record

ArticleArquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery2026

Nissen Fundoplication: 70 years of a simple and brilliant idea in the surgical treatment of gastroesophageal reflux disease.

Fernando Antonio Siqueira Pinheiro, Jean Claude Boulez, Nelson Adami Andreollo, Paulo Kassab

Abstract readHistorical Article
In one paragraph

Article in Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fernando Antonio Siqueira PinheiroUniversidade Federal do Ceará, Faculty of Medicine, Walter Cantídio University Hospital, Esophageal and Stomach Surgery Unit, Department of Surgery - Fortaleza (CE), Brazil.ORCID http://orcid.org/0000-0003-4480-6877
Jean Claude BoulezClaude Bernard University, Édouard Herriot Hospital, Digestive Surgery Service - Lyon, France.ORCID http://orcid.org/0009-0007-2497-6787
Nelson Adami AndreolloUniversidade Estadual de Campinas, Department of Surgery - Campinas (SP), Brazil.ORCID http://orcid.org/0000-0001-7452-1165
Paulo KassabSanta Casa de Misericórdia de São Paulo, Faculty of Medical Sciences, Department of Surgery, Gastroesophageal and Bariatric Surgery Unit - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-5115-6297

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rudolf Nissen published his first two cases in 1956, thus inaugurating the era of pathological gastroesophageal reflux surgery. From the 1970s onwards, with Nissen fundoplication increasingly used as the treatment of choice for gastroesophageal reflux and hiatal hernia, minor alterations were proposed. Nissen's greatest legacy: not just an operation, but a way of thinking about surgery as a restless, rigorous, and profoundly patient-centered procedure.

Indexed as

FundoplicationGastroesophageal RefluxHistory, 20th CenturyHumans

Identifiers

PMID42659517
PMCPMC13498306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.