Evidence map›Paper›PMID 42659437›Full record

ArticleEinstein (Sao Paulo, Brazil)2026

Management of oral Pseudomonas aeruginosa infections in oncology patients using antimicrobial photodynamic therapy, photobiomodulation, and systemic antibiotics: a case series.

Marcella Ferreira Gobbi, Fernanda de Paula Eduardo, Nidia Castro Dos Santos, Giovana Ferrari Molina, Patrick Polcaro de Paiva Santos, Danielle Lima Corrêa de Carvalho, Leticia Mello Bezinelli

Abstract read
In one paragraph

Article in Einstein (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marcella Ferreira GobbiFaculdade de Odontologia, Universidade de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-7351-8431
Fernanda de Paula EduardoFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-6939-988X
Nidia Castro Dos SantosFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-2041-9426
Giovana Ferrari MolinaFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0009-0006-1236-3169
Patrick Polcaro de Paiva SantosFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0009-0003-6528-0795
Danielle Lima Corrêa de CarvalhoFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-1352-8640
Leticia Mello BezinelliFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-8635-0508

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe a case series of oral Pseudomonas aeruginosa infections in oncology patients managed using combined antimicrobial photodynamic therapy and photobiomodulation in association with systemic antibiotic therapy guided by microbiological culture and antibiogram.

methodsNine oncology patients with culture-confirmed oral Pseudomonas aeruginosa infections were treated with alternating sessions of antimicrobial photodynamic therapy and photobiomodulation combined with systemic antibiotic therapy selected according to antibiogram results. Clinical response, healing time, and microbiological findings were evaluated.

resultsAll patients achieved complete resolution of oral lesions, with a median healing time of 5 days (range, 3-16 days). Microbiological analysis demonstrated high resistance rates to fluoroquinolones and cephalosporins, whereas all isolates remained sensitive to aminoglycosides. No adverse effects or recurrences were observed during follow-up.

conclusionCombined antimicrobial photodynamic therapy and photobiomodulation associated with systemic antibiotic therapy guided by culture and antibiogram proved to be a safe, rapid, and reproducible adjunctive approach for managing multidrug-resistant oral infections in oncology patients. Controlled clinical trials are warranted.

Indexed as

Anti-Bacterial AgentsLow-Level Light TherapyNeoplasmsPhotochemotherapyPseudomonas aeruginosaPseudomonas InfectionsAdultAgedCombined Modality TherapyFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedTreatment OutcomeAnti-Bacterial Agents

Identifiers

PMID42659437
PMCPMC13689963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.