Evidence map›Paper›PMID 42659420›Full record

ReviewBrazilian oral research2026

Photobiomodulation in the management of oral lesions: a targeted, evidence-based approach.

Valesca Sander Koth, Amanda de Farias Gabriel, Iohanna Deckmann, Rogerio Moraes Castilho, Felipe Nor, Marcelo Lazzaron Lamers, José Antonio Poli de Figueiredo, Manoela Domingues Martins

Abstract readReview
In one paragraph

Review in Brazilian oral research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Valesca Sander KothUniversidade Federal of Rio Grande do Sul - UFRGS, School of Dentistry, Department of Oral Pathology, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-5119-7347
Amanda de Farias GabrielUniversidade Federal of Rio Grande do Sul - UFRGS, School of Dentistry, Department of Oral Pathology, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-8910-5815
Iohanna DeckmannUniversidade Federal of Rio Grande do Sul - UFRGS, Institute of Basic Health Sciences, Department of Morphological Sciences, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-6423-1938
Rogerio Moraes CastilhoUniversity of Michigan School of Dentistry, Department of Periodontics and Oral Medicine, Ann Arbor, MI, United States.ORCID http://orcid.org/0000-0001-5358-612X
Felipe NorUniversity of Michigan School of Dentistry, Department of Periodontics and Oral Medicine, Ann Arbor, MI, United States.ORCID http://orcid.org/0000-0002-7429-5441
Marcelo Lazzaron LamersUniversidade Federal of Rio Grande do Sul - UFRGS, Institute of Basic Health Sciences, Department of Morphological Sciences, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0001-5296-5662
José Antonio Poli de FigueiredoUniversidade Federal of Rio Grande do Sul - UFRGS, Institute of Basic Health Sciences, Department of Morphological Sciences, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-8113-9260
Manoela Domingues MartinsUniversidade Federal of Rio Grande do Sul - UFRGS, School of Dentistry, Department of Oral Pathology, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0001-8662-5965

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review synthesizes current literature on laser applications in dentistry, with particular emphasis on the biological mechanisms of photobiomodulation (PBM), dosimetric considerations, tissue interactions, and the clinical management of the most prevalent oral lesions. The oral disorders most frequently investigated for the therapeutic use of PBM were: a) oral pain conditions: trigeminal neuralgia, temporomandibular disorders, and burning mouth syndrome; b) oncology-related conditions: oral mucositis and hyposalivation; c) immune-mediated disorders: recurrent aphthous stomatitis and oral lichen planus; and d) viral infections: herpes labialis. A wide range of laser parameters has shown clinical benefits in the treatment of these disorders. These outcomes are attributed to the anti-inflammatory, analgesic, and tissue repair effects of PBM, which may occur immediately and cumulatively over repeated sessions. PBM therapy is a valuable therapeutic resource in contemporary dentistry and may be successfully applied in a wide range of clinical conditions. Clinical effectiveness of PBM depends on appropriate dosimetry and irradiation parameters according to the biological characteristics of each condition and therapeutic target. Therefore further well-designed randomized clinical trials and protocol standardization are still required to strengthen clinical recommendations and optimize reproducibility.

Indexed as

Low-Level Light TherapyMouth DiseasesEvidence-Based DentistryHumansStomatitisTreatment Outcome

Identifiers

PMID42659420
PMCPMC13508680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.