Evaporation-free Supercritical Fluid Chromatography-Internal Standard Correction-Solvent Suppression-Quantitative Nuclear Magnetic Resonance for Chiral Separation and Quantification of Quinine.

Jiaxin Wang, Huan Yao, Ting Huang, Wei Zhang, Zhaoming Ran, Ping Su, Yi Yang

Abstract read

In one paragraph

Article in Journal of separation science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiaxin WangCollege of Chemistry, Beijing University of Chemical Technology, Beijing, P. R. China.

Huan YaoDivision of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing, P. R. China.

Ting HuangDivision of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing, P. R. China.

Wei ZhangDivision of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing, P. R. China.

Zhaoming RanDivision of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing, P. R. China.

Ping SuCollege of Chemistry, Beijing University of Chemical Technology, Beijing, P. R. China.

Yi YangCollege of Chemistry, Beijing University of Chemical Technology, Beijing, P. R. China.

Funding

National Key Research and Development Program of China 2023YFF0612602National Natural Science Foundation of China 22304169

6 · The paper itself

Abstract

Accurate quantification of structurally similar impurities in chiral drugs remains a critical challenge in pharmaceutical quality control. Herein, we established supercritical fluid chromatography-internal standard correction-solvent suppression-quantitative nuclear magnetic resonance (SFC-ISC-SS-qNMR) for the rapid and accurate purity assessment of low-purity quinine (QN). Baseline separation of QN from its chiral isomer quinidine was achieved within 10 min using SFC. The collected eluate, without any nitrogen blowing or freeze-drying, was directly mixed with an IS and a trace amount of deuterium oxide for

Indexed as

chiral separationpharmaceutical purity assessmentquantitative NMRquininesolvent suppressionsupercritical fluid chromatography

Identifiers

PMID42658898

DOI10.1002/jssc.70518

PMCPMC13521454

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.