pH-Driven Actuation of Unmodified DNA Origami Rectangles.

Diego A Uehara, Yasmin H Khazid, Willi R Berg, Veronika Valova, Felix J Rizzuto

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Diego A UeharaSchool of Chemistry, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0009-0007-9683-1587

Yasmin H KhazidSchool of Chemistry, University of New South Wales, Sydney, Australia.

Willi R BergSchool of Chemistry, University of New South Wales, Sydney, Australia.

Veronika ValovaElectron Microscope Unit, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0009-0004-0758-5248

Felix J RizzutoSchool of Chemistry, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0003-2799-903X

Funding

Australian Research Council Discovery Early Career Research Award DE220100558Australian Research Council Discovery Projects DP250100041Australian Research Council Discovery Projects DP250100081Electron Microscope Unit

6 · The paper itself

Abstract

DNA origami is a versatile method for constructing molecular machinery, yet many designs rely on responsive motifs or added components to achieve dynamic behavior. Here, we show that unmodified DNA origami rectangles-one of the most widely used DNA origami structures-exhibit a reversible transition between planar and tubular states upon pH modulation. We propose that this transformation occurs due to the cooperative mechanical coupling of crossover junctions in overwound DNA: no DNA modification, special sequences, or extra motifs are needed. The curling/uncurling response extends to connected rectangles: dimers and nanoribbons curl reversibly below pH 7 to form nanotube architectures. This unexpected conformational flexibility of monolayer DNA with pH provides a simple framework for engineering responsive nanostructures that can be transformed without chemical modification or specific sequence motifs.

Indexed as

DNADNA NanostructuresHydrogen-Ion ConcentrationNucleic Acid ConformationDNAactuationDNA origamimolecular machinespH modulationself‐assembly

Identifiers

PMID42658862

DOI10.1002/anie.7118770

PMCPMC13638106

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.