ArticlePloS one2026
Enhancing uptake of PrEP for her via organizational research and individual actions (EUPHORIA): Protocol for a stepped-wedge cluster randomized trial.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundBlack/African American cisgender women (hereafter referred to as "Black women") experience one of the highest incidences of HIV yet are often not prioritized in HIV prevention initiatives. For example, pre-exposure prophylaxis (PrEP) for HIV prevention continues to be under-prescribed to women despite its proven effectiveness and demonstrated impact on mitigating HIV transmission. Increasing PrEP initiation and persistence among women through tailored implementation strategies remains crucial to HIV prevention efforts, yet few studies have been designed for women, particularly within the context of family planning centers. This article outlines the study protocol to evaluate the effectiveness of implementation strategies ("EUPHORIA") to improve PrEP care continuum outcomes and to address barriers to PrEP uptake among women in family planning centers in Cook County, Illinois.
methodsThis study builds upon previous work to adapt implementation strategies for increasing PrEP uptake among Black women. The intervention will consist of implementing a combination of strategies and measuring the impact on PrEP utilization among Black women at 8 family planning centers via a stepped-wedge cluster randomized trial. A mixed-methods approach will be utilized to evaluate implementation outcomes and assess the feasibility, acceptability, and effectiveness of the strategies. DISCUSSION: As a result of the intervention, we anticipate that Black women within selected health centers will be more likely to receive PrEP prescriptions. During post-implementation analysis, we will identify key barriers and facilitators within the PrEP care continuum during the implementation process at the patient, provider, and system levels. This study contributes to addressing the inequity in PrEP delivery, aiming to increase initiation and persistence of PrEP for women in family planning centers. If determined effective, these implementation strategies will be further disseminated for use in similar family planning health centers and for future study in potential scale-up.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.