ArticlePloS one2026
Quantitative analysis of choroidal and retinal thickness and blood flow in a rat model of lens-induced myopia using OCTA.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to use optical coherence tomography angiography (OCTA) to quantitatively analyze the changes in the thickness of the choroidal and retinal layers as well as the alterations in intraretinal blood flow in lens-induced myopia (LIM) rats, and to provide a basis for mechanistic studies of myopia models from the perspective of the choroid and the retina.
methodsWe conducted LIM modeling in rats and set up a normal control (NC). After 8 weeks of modeling, use a high-resolution anterior and posterior segment biometric OCTA to measure the axial length, choroidal thickness, and the thickness of the inner, outer, and entire retinal layers in two groups of rats, and quantify changes in blood flow in the inner layer of the retina. The results were analyzed using t-test.
resultsCompared with NC, LIM rats had longer axis, thinner choroid thickness, thinner inner, outer and whole retinal thickness, and lower blood flow density in inner retina. The differences were statistically significant at most measurement points.
conclusionsOCTA revealed three myopia hallmarks: axial elongation, choroidal/retinal thinning, and retinal hypoperfusion. These findings enhance clinical understanding of myopic morphological changes and provide mechanistic insights into choroidal-retinal contributions. OCTA's noninvasive high-resolution enables longitudinal monitoring of ocular structural/vascular changes, offering a basis for diagnosing and preventing high-myopia retinopathy. TRANSLATIONAL RELEVANCE: This study used OCTA to non-invasively quantify retinal and choroidal structure and blood flow abnormalities in a myopia animal model, providing translatable imaging biomarkers for the early clinical screening of retinal lesions associated with high myopia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.