Evidence map›Paper›PMID 42658767›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Cell competition driven by secreted ligands: Modeling liver metastasis of colorectal cancer.

Hossein Nemati, Saskia Jacoba Elisabeth Suijkerbuijk, Joost de Graaf

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cell competition driven by secreted ligands: Modeling liver metastasis of colorectal cancer.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hossein NematiInstitute for Theoretical Physics, Department of Physics, Faculty of Science, Utrecht University, Princetonplein 5, Utrecht 3584 CC, The Netherlands.ORCID 0000-0003-1289-4155
Saskia Jacoba Elisabeth SuijkerbuijkDivision of Developmental Biology, Institute of Biodynamics and Biocomplexity, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands.ORCID 0000-0002-3197-1307
Joost de GraafInstitute for Theoretical Physics, Department of Physics, Faculty of Science, Utrecht University, Princetonplein 5, Utrecht 3584 CC, The Netherlands.ORCID 0000-0002-8781-7368

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) 740.018.013
6 · The paper itself

Abstract

Cell competition in multicellular organisms has been shown to play a critical role during the development of organisms, cancer progression, and in the establishment and maintenance of tissue homeostasis. Various mechanisms of cell competition have been identified, including active elimination via mechanical forces or induced apoptosis, as well as competition for nutrients and other beneficial factors. A recent experiment demonstrated hallmarks of cell competition, associated with cell cycle dynamics, between liver progenitor cells and colorectal cancer cells [A. Krotenberg Garcia et al.,

Indexed as

Cell CompetitionColorectal NeoplasmsLiver NeoplasmsModels, BiologicalCell CycleHumansLigandsSignal TransductionLigandscell competitioncell cycleconsumer–resource modelingmean-field modelphysical modeling

Identifiers

PMID42658767
PMCPMC13535163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.