ArticleCell reports2026
Prohibitin controls MRS2-Mediated mitochondrial Mg
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Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
21 authors.
Soumya MaityCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Manigandan VenkatesanCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA. Electronic address: venkatesanm@uthscsa.edu.
Adhishree ChidambaramCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Sukanthathulse UthayabalanDepartment of Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada.
Louis Tung Faat LaiUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Nicholas D ClarkUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Abhinaya LakkureddiCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Karthik RamachandranCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Kristen BentzCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Ravi RamalingamCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Sanjana SenCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Moeez AkramCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Susan T WeintraubCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Brij B SinghDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
David GiusDepartment of Radiation Oncology, Mays Cancer Center MD Anderson, and the Joe R. and Teresa Lozano Long School of Medicine, University of Texas San Antonio Health Science Center, San Antonio, TX, USA.
Joseph A BaurDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19103, USA.
Arianne L TheissDivision of Gastroenterology and Hepatology, Department of Medicine, University of Colorado School of Medicine and Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO 80045, USA.
Jeffrey CaplanDepartment of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA.
Doreen MatthiesUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Peter B StathopulosDepartment of Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada. Electronic address: peter.stathopulos@schulich.uwo.ca.
Muniswamy MadeshCenter for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA. Electronic address: muniswamy@uthscsa.edu.
Funding
Towards high-resolution structural biology of membrane protein complexes in their native lipid environmentZIAHD008998 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MATTHIES, DOREEN · 2021 to 2025
$10.7MSpectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3MMagnesium flux compendium: Discover ligands, channels, and metabolic signalsR35GM145294 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MADESH MUNISWAMY · 2022 to 2026
$2.9MMechanisms and therapeutic potential of blocking the mitochondrial Mg2+ channel Mrs2 in obesity and NAFLDR01DK135179 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Joseph A. Baur, MADESH MUNISWAMY · 2023 to 2026
$2.1MControl of Endothelial Mechanotransduction by the Mitochondrial Ca2+ Uniporter: Implications for AtherosclerosisR01HL142673 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ALEVRIADOU, BARBARA RITA, MUNISWAMY, MADESH · 2018 to 2021
$2.0MCharacterize TMEM94 as ER Mg2+ uptake machinery and pathophysiological consequences.R01HL175081 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MADESH MUNISWAMY · 2025 to 2026
$1.1MOrbitrap XL/ETD Mass SpectrometerS10RR025111 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI WEINTRAUB, SUSAN T · 2009 to 2009
$776kEssential Role for SPG7 in Mitochondrial Permeability Transition Pore Assembly and FunctionR01GM135760 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2020 to 2021
$613kBLRD VA I01 BX005288Intramural NIH HHS ZIA HD008998NCRR NIH HHS S10 RR025111NHLBI NIH HHS R01 HL142673NHLBI NIH HHS R01 HL175081NIDDK NIH HHS R01 DK135179NIGMS NIH HHS R01 GM109882NIGMS NIH HHS R01 GM135760NIGMS NIH HHS R35 GM145294
Abstract
Mitochondrial magnesium (
Indexed as
Energy MetabolismMagnesiumMitochondriaRepressor ProteinsAnimalsCalciumHepatocytesHumansMiceProhibitinsCalciumMagnesiumPHB protein, humanProhibitinsRepressor ProteinsbioenergeticscalciumchannelCP: molecular biologyendoplasmic reticulummagnesiumMCUmetabolismmitochondriaMRS2PHBprohibitinstructure
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.