Evidence map›Paper›PMID 42658424›Full record

ReviewJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2026

The importance of classifying central hypopneas: a call to action.

Anjali P Ahn, Ali Azarbarzin, M Safwan Badr, Richard Berry, Pamela DeYoung, Kara Dupuy-McCauley, Timothy I Morgenthaler, Jean Louis Pépin, Winfried Randerath, Scott Sands and 2 more

Abstract readReview
In one paragraph

Review in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Central hypopnea classification: bridging the gap between event identification and clinical utility.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anjali P AhnDepartment of Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. aahn1@bidmc.harvard.edu.ORCID http://orcid.org/0009-0007-6307-1091
Ali AzarbarzinDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
M Safwan BadrDepartment of Internal Medicine, University Health Center, Wayne State University School of Medicine, Detroit, MI, USA.
Richard BerryDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, FL, USA.
Pamela DeYoungCenter for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Kara Dupuy-McCauleyCenter for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Timothy I MorgenthalerCenter for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Jean Louis PépinHP2 Laboratory, University Grenoble Alpes, INSERM, CHU Grenoble Alpes, Grenoble, France.
Winfried RanderathClinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
Scott SandsDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Sudha TallavajhulaDepartment of Neurology, Epilepsy Division, University of Texas Health Sciences Center, Houston, TX, USA.
Atul MalhotraDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, USA.

Funding

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

Obstructive and central sleep apnea share pathophysiologic features and often coexist within individual patients. There is general agreement on the criteria for scoring obstructive and central apneas but less guidance and clarity on how and when to classify obstructive and central hypopneas. This paper is an expert panel discussion that examines the importance of accurately classifying obstructive from central hypopneas and the implications of this distinction for both diagnosis and treatment of sleep-disordered breathing. The physiologic and polysomnographic features that allow hypopneas to be classified as either obstructive or central are discussed. When hypopneas are systematically classified, a substantial number of patients are found to have a high proportion of coexisting central disease. The authors discuss how hypopnea classification has growing importance in evaluating patients for neurostimulation and emerging pharmacologic therapies. Finally, the authors outline the need for reproducible approaches to hypopnea classification.

Indexed as

Sleep Apnea, CentralSleep Apnea, ObstructiveHumansPolysomnography

Identifiers

PMID42658424
PMCPMC13522320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.