Evidence map›Paper›PMID 42658394›Full record

ArticleAnnals of biomedical engineering2026

Fracking in Tumors: A Key Drug Transport Mechanism.

Vitor Mori, Atena Farhangian, Dylan T Casey, Jacob S Warner, Chris Thomson, Kurt Schulz, Nirav Daphtary, Minara Aliyeva, Loa Georgesdottir, McCarthy Kennedy and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vitor Mori *Division of Pulmonary and Critical Care, Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.ORCID http://orcid.org/0000-0001-7515-8812
Atena Farhangian *Division of Pulmonary and Critical Care, Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
Dylan T CaseyDivision of Pulmonary and Critical Care, Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
Jacob S WarnerDivision of Pulmonary and Critical Care, Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
Chris ThomsonEthos Discovery, Woburn, MA, USA.
Kurt SchulzEthos Discovery, Woburn, MA, USA.
Nirav DaphtaryDivision of Pulmonary and Critical Care, Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
Minara AliyevaDivision of Pulmonary and Critical Care, Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
Loa GeorgesdottirDivision of Pulmonary and Critical Care, Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
McCarthy KennedyDivision of Pulmonary and Critical Care, Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
Chad E EckertJohnson and Johnson, Interventional Oncology, New Brunswick, NJ, USA.
Nicole StorerJohnson and Johnson, Interventional Oncology, New Brunswick, NJ, USA.
Jason H T BatesDivision of Pulmonary and Critical Care, Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
C Matthew KinseyDivision of Pulmonary and Critical Care, Larner College of Medicine at the University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA. matt.kinsey@med.uvm.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo understand the pharmacokinetic and biophysical mechanisms governing how an intratumorally injected agent is ultimately retained and distributed within a tumor and how it can guide injections at the bedside.

methodsWe injected a radiopaque agent at clinically relevant constant flows into nine freshly resected canine lung tumors while continuously monitoring the fluid pressure,

results

conclusionThis interpretation suggests that real-time monitoring of

Indexed as

Drug retentionHydraulic fractureIntratumoral drug deliveryIntratumoral injectionsIntratumoral transport

Identifiers

PMID42658394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.