ArticleIntensive care medicine experimental2026
Exploring the temporal statistical relationship between commercial cerebral near-infrared spectroscopy signals and intracranial pressure in traumatic brain injury.
Noah Silvaggio, Kevin Y Stein, Makenna Coldwell, Vuk Roca, Amanjyot Singh Sainbhi, Isuru Herath, Tobias Bergmann, Rakibul Hasan, Mansoor Hayat, Jaewoong Moon and 1 more
Abstract read
In one paragraphArticle in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Makenna ColdwellGraduate Program in Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, Canada.
Vuk RocaUndergraduate Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB, Canada.
Isuru HerathGraduate Program in Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, Canada.
Rakibul HasanGraduate Program in Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, Canada.
Mansoor HayatSection of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Jaewoong MoonSection of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Funding
Canada Foundation for Innovation 38583CIHR 530549Endowed Manitoba Public Insurance (MPI) Chair in Neuroscience/TBI Research Endowment Endowed Manitoba Public Insurance (MPI) Chair in Neuroscience/TBI Research EndowmentHealth Sciences Centre Foundation Winnipeg Health Sciences Centre Foundation WinnipegMPI Neuroscience Research Operating Fund MPI Neuroscience Research Operating FundNSERC ALLRP-576386-22NSERC ALLRP-578524-22NSERC ALLRP-586244-23NSERC ALLRP-590680-2023,NSERC ALLRP-597442-24NSERC ALLRP-597708-24NSERC DGECR-2022-00260NSERC I2IPJ-586104-23NSERC I2IPJ-598125-24NSERC RGPIN-2022-03621NSERC CGS-D program CGS D-579021-2023NSERC CGS-M program NSERC CGS-M programNSERC PGS-D program PGS D-600443-2025Pan Am Clinic Foundation of Winnipeg. Pan Am Clinic Foundation of Winnipeg.Research Manitoba 3906Research Manitoba 5429Research Manitoba 5914Research Manitoba 6554Research Manitoba 7312Research Manitoba Master's Studentship Award Research Manitoba Master's Studentship AwardResearch Manitoba Post-Doctoral Fellowship Research Manitoba Post-Doctoral FellowshipUniversity of Manitoba Graduate Enhancement of Tri-Agency Stipends (GETS) program University of Manitoba Graduate Enhancement of Tri-Agency Stipends (GETS) programUniversity of Manitoba Graduate Enhancement of Tri-Agency Stipends (GETS) program. University of Manitoba Graduate Enhancement of Tri-Agency Stipends (GETS) program.University of Manitoba Graduate Fellowship (UMGF) in Biomedical Engineering University of Manitoba Graduate Fellowship (UMGF) in Biomedical EngineeringUniversity of Manitoba Graduate Fellowship (UMGF) in Biomedical Engineering. University of Manitoba Graduate Fellowship (UMGF) in Biomedical Engineering.University of Manitoba MD/PhD program University of Manitoba MD/PhD programUniversity of Manitoba R.G. and E.M. Graduate Fellowship (Doctoral) in Biomedical Engineering University of Manitoba R.G. and E.M. Graduate Fellowship (Doctoral) in Biomedical Engineering
6 · The paper itselfAbstract
backgroundMonitoring of intracranial pressure (ICP) is important for not only assessing neurological status of patients following traumatic brain injury (TBI), but also for guiding therapeutic interventions for the prevention of secondary neurological injury. Although current ICP monitoring techniques are highly temporally accurate, they come with some significant limitations. These limitations include the invasive nature, expertise required for placement of these devices, high cost associated with maintenance, and poor spatial resolution. Cerebral near-infrared spectroscopy (NIRS) offers a non-invasive alternative technique for cerebral physiological monitoring. This modality eliminates the need for surgical expertise, as well as decreasing the financial cost associated with monitoring cerebral physiology. Preliminary evidence has pointed to a potential link between the NIRS variable, regional oxygen saturation (rSO
resultsUtilizing retrospective high-frequency physiologic data from a population of 118 TBI patients across different temporal resolutions and data window sizes, we evaluated independent statistical signal structure of rSO
conclusionFindings from this study demonstrate convergence in the temporal statistical behaviour of ICP and rSO
Indexed as
Cerebral near-infrared spectroscopyICPIntracranial pressureNIRSRegional oxygen saturationRSO2
Identifiers
PMID42658381
PMCPMC13522304
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