ReviewCurrent heart failure reports2026
Opioid Use for Dyspnoea in Advanced Heart Failure.
Review in Current heart failure reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThis narrative review aims to provide an overview of the available evidence on opioid use for refractory dyspnoea in advanced heart failure, focusing on mechanisms, effectiveness, safety, patient selection, and their possible role within a palliative care approach. Evidence from clinical trials and observational studies is presented and practical recommendations about opioid use in patients with refractory dyspnoea in advanced heart failure are provided. RECENT
findingsDyspnoea in advanced heart failure is a multidimensional symptom that may persist despite optimal medical therapy. Randomised trials have shown mixed and limited benefits for chronic dyspnoea, while observational studies suggest that opioids can provide clinically relevant short-term relief of refractory dyspnoea in advanced heart failure, with an overall manageable safety profile. In contrast, opioid use in acute heart failure has been associated with worse outcomes. Despite mixed and limited evidence, opioids may be considered for symptom relief in selected patients with advanced heart failure and chronic refractory dyspnoea when used cautiously. Their use should be individualized based on individual patients' characteristics. Opioid use should be avoided in acute heart failure management. Further research is needed to better define patient selection and optimal use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.