Evidence map›Paper›PMID 42658266›Full record

ReviewInternational orthopaedics2026

Hybrid Assistive Limb in orthopaedic rehabilitation: cybernic treatment developed in Japan for neuromotor functional restoration.

Kousei Miura, Yuichiro Soma, Yukiyo Shimizu, Hideki Kadone, Shigeki Kubota, Seioh Ezaki, Hiroshi Noguchi, Hiroshi Takahashi, Yasuhiro Homma, Masashi Yamazaki

Abstract readReview
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In one paragraph

Review in International orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kousei MiuraDepartment of Orthopaedic Surgery, Moriya Daiichi General Hospital, Moriya, Japan. kmiura@tsukuba-seikei.jp.ORCID https://orcid.org/0000-0001-7826-184X
Yuichiro SomaDepartment of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Yukiyo ShimizuDepartment of Rehabilitation Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Hideki KadoneCenter for Innovating Medicine and Engineering (CIME), University of Tsukuba, Tsukuba, Japan.
Shigeki KubotaDepartment of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Seioh EzakiDepartment of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Hiroshi NoguchiDepartment of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Hiroshi TakahashiDepartment of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Yasuhiro HommaDepartment of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Masashi YamazakiDepartment of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe Hybrid Assistive Limb (HAL) is a wearable cyborg system that uses surface bioelectrical signals to assist movement at the same time as the wearer's voluntary effort. This review explains its control principles and assesses the clinical evidence relevant to orthopaedic rehabilitation.

methodsPublished clinical studies of HAL in orthopaedic rehabilitation were reviewed narratively and grouped by device configuration and clinical indication.

resultsAcross spinal cord injury and post-operative compressive myelopathy, training with the HAL lower-limb type was associated with improvements in walking speed, endurance, balance, trunk function and gait coordination. After total knee arthroplasty, the HAL single-joint and lower-limb types were associated with earlier gains in knee extension, less extension lag and pain, and better walking measures. In older adults, the HAL lumbar type supported repeated sit-to-stand and other hip-extension tasks, and improvements in mobility were reported. Upper-limb applications allowed assisted joint practice using weak residual muscle activity. Kinematic, electromyographic, motor-unit and cortical findings suggest that assistance linked to voluntary effort may influence sensorimotor activity during training.

conclusionHAL offers a distinctive approach to orthopaedic rehabilitation by turning residual bioelectrical activity into well-timed movement assistance and repeated sensory feedback. Available studies suggest that this approach can increase opportunities for voluntary, task-specific practice and may help to improve walking, joint movement and functional mobility in spinal and musculoskeletal conditions. These findings support the continued clinical development and evaluation of HAL as a rehabilitation option that responds to the user's intention.

Indexed as

Hybrid Assistive LimbOrthopaedic rehabilitationRobot-assisted rehabilitationSpinal cord injuryWearable cyborg

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.