Evidence map›Paper›PMID 42658259›Full record

ReviewIntensive care medicine2026

Balancing lung and brain: physiological strategies for ARDS management in acute brain injury.

Chiara Robba, Nekane Romero-García, Shaurya Taran, Rafael Badenes, Luigi Camporota, Patricia R M Rocco, Mariangela Pellegrini, Lise Piquilloud, Antoine Roquilly, Matthieu Schmidt and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chiara RobbaAOM IRCCS Policlinico San Martino, Genoa, Italy. kiarobba@gmail.com.ORCID http://orcid.org/0000-0003-1628-3845
Nekane Romero-GarcíaDepartment of Anesthesiology and Critical Care, Hospital Clínic Universitari de Valencia, University of Valencia, Valencia, Spain.
Shaurya TaranToronto Western Hospital, University Health Network, University of Toronto, Toronto, Canada.
Rafael BadenesDepartment of Anesthesiology and Critical Care, Hospital Clínic Universitari de Valencia, University of Valencia, Valencia, Spain.
Luigi CamporotaDivision of Anaesthetics, Pain Medicine and Intensive Care (APMIC), Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Patricia R M RoccoLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Mariangela PellegriniAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Lise PiquilloudAdult Intensive Care Unit, University Hospital and University of Lausanne, Lausanne, Switzerland.
Antoine RoquillyInserm, CHU Nantes, Center for Research in Transplantation and Translational Immunology, Nantes Université, Nantes, France.
Matthieu SchmidtInstitute of Cardiometabolism and Nutrition, INSERM Unité Mixte de Recherche (UMRS) 1166, Service de Médecine Intensive-Réanimation, Institut de Cardiologie, Assistance Publique-Hôpitaux de Paris (APHP) Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris, France.
Fabio Silvio TacconeDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Sarah WahlsterDepartments of Neurology Neurosurgery, and Anesthesiology, University of Washington, Seattle, USA.
Nicolò Antonino PatronitiAOM IRCCS Policlinico San Martino, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is a common and clinically significant complication in patients with acute brain injury (ABI), affecting up to one-third of critically ill individuals and contributing to increased mortality, prolonged mechanical ventilation, and worse neurological outcomes. The coexistence of ARDS and ABI creates a fundamental therapeutic dilemma: strategies that protect the lung may adversely affect cerebral physiology, whilst neuroprotective targets may compromise respiratory management. This narrative review examined the pathophysiological interactions between the injured lung and brain, highlighting the competing effects of key ventilatory variables. Lung-protective ventilation, including low tidal volume and higher positive end-expiratory pressure (PEEP), reduces ventilator-induced lung injury but may increase arterial carbon dioxide (PaCO

Indexed as

BrainBrain InjuriesLungRespiration, ArtificialRespiratory Distress SyndromeHumansPositive-Pressure RespirationAcute brain injuryAcute respiratory distress syndromeDriving pressureHypercapniaMechanical ventilationOxygenation

Identifiers

PMID42658259
PMCPMC13562141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.